دورية أكاديمية
Daratumumab during Myeloma Induction Therapy Is Associated with Impaired Stem Cell Mobilization and Prolonged Post-Transplant Hematologic Recovery. ...
| العنوان: | Daratumumab during Myeloma Induction Therapy Is Associated with Impaired Stem Cell Mobilization and Prolonged Post-Transplant Hematologic Recovery. ... |
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| المؤلفون: | Mehl, Julian, Akhoundova, Dilara, Bacher, Ulrike, Jeker, Barbara, Rhyner Agocs, Gaëlle, Ruefer, Axel, Soltermann, Susanne, Soekler, Martin, Winkler, Annette, Daskalakis, Michael, Pabst, Thomas |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | 610 Medicine & health |
| الوصف: | Daratumumab is being increasingly integrated into first-line multiple myeloma (MM) induction regimens, leading to improved response depth and longer progression-free survival. Autologous stem cell transplantation (ASCT) is commonly performed as a consolidation strategy following first-line induction in fit MM patients. We investigated a cohort of 155 MM patients who received ASCT after first-line induction with or without daratumumab (RVd, n = 110; D-RVd, n = 45), analyzing differences in stem cell mobilization, apheresis, and engraftment. In the D-RVd group, fewer patients successfully completed mobilization at the planned apheresis date (44% vs. 71%, p = 0.0029), and more patients required the use of rescue plerixafor (38% vs. 28%, p = 0.3052). The median count of peripheral CD34+ cells at apheresis was lower (41.37 vs. 52.19 × 106/L, p = 0.0233), and the total number of collected CD34+ cells was inferior (8.27 vs. 10.22 × 106/kg BW, p = 0.0139). The time to recovery of neutrophils and platelets was ... |
| نوع الوثيقة: | text article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://dx.doi.org/10.3390/cancers16101854Test |
| DOI: | 10.48350/197093 |
| الإتاحة: | https://doi.org/10.48350/19709310.3390/cancers16101854Test https://boris.unibe.ch/197093Test/ |
| حقوق: | open access ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcodeTest ; cc-by-4.0 ; http://purl.org/coar/access_right/c_abf2Test |
| رقم الانضمام: | edsbas.B2E8E815 |
| قاعدة البيانات: | BASE |
| DOI: | 10.48350/197093 |
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