دورية أكاديمية
Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action
| العنوان: | Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action |
|---|---|
| المؤلفون: | Viader, Andreu, Blankman, Jacqueline L., Zhong, Peng, Liu, Xiaojie, Scholsburg, Joel E., Joslyn, Christopher M., Liu, Qing-Song, Tomarchio, Aaron J., Lichtman, Aron H., Selley, Dana E., Sim-Selley, Laura J., Cravatt, Benjamin F. |
| المصدر: | Pharmacology and Toxicology Publications |
| بيانات النشر: | VCU Scholars Compass |
| سنة النشر: | 2015 |
| المجموعة: | Virginia Commonwealth University: VCU Scholars Compass |
| مصطلحات موضوعية: | endocannabinoid, monoacylglycerol lipase, neuroinflammation, prostaglandin, synaptic plasticity, receptor desensitization, transcellular metabolism, Medical Pharmacology |
| الوصف: | The endocannabinoid 2-arachidonoylglycerol (2-AG) is a retrograde lipid messenger that modulates synaptic function, neurophysiology, and behavior. 2-AG signaling is terminated by enzymatic hydrolysis—a reaction that is principally performed by monoacylglycerol lipase (MAGL). MAGL is broadly expressed throughout the nervous system, and the contributions of different brain cell types to the regulation of 2-AG activityin vivo remain poorly understood. Here, we genetically dissect the cellular anatomy of MAGL-mediated 2-AG metabolism in the brain and show that neurons and astrocytescoordinately regulate 2-AG content and endocannabinoid-dependent forms of synaptic plasticity and behavior. We also find that astrocytic MAGL is mainly responsible for converting 2-AG to neuroinflammatory prostaglandins via a mechanism that may involve transcellular shuttling of lipid substrates. Astrocytic-neuronal interplay thus provides distributed oversight of 2-AG metabolism and function and, through doing so, protects the nervous system from excessive CB1 receptor activation and promotes endocannabinoid crosstalk with other lipid transmitter systems. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://scholarscompass.vcu.edu/phtx_pubs/37Test; https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1039&context=phtx_pubsTest |
| الإتاحة: | https://scholarscompass.vcu.edu/phtx_pubs/37Test https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1039&context=phtx_pubsTest |
| حقوق: | Copyright © 2015 The Authors. Published by Elsevier Inc. |
| رقم الانضمام: | edsbas.B2CD1290 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |