دورية أكاديمية
A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation
| العنوان: | A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation |
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| المؤلفون: | Das, Sudip, Bernasconi, Eric, Koutsokera, Angela, Wurlod, Daniel-Adrien, Tripathi, Vishwachi, Bonilla-Rosso, Germán, Aubert, John-David, Derkenne, Marie-France, Mercier, Louis, Pattaroni, Céline, Rapin, Alexis, von Garnier, Christophe, Marsland, Benjamin J., Engel, Philipp, Nicod, Laurent P. |
| المصدر: | Nature Communications ; volume 12, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
| الوصف: | There is accumulating evidence that the lower airway microbiota impacts lung health. However, the link between microbial community composition and lung homeostasis remains elusive. We combine amplicon sequencing and bacterial culturing to characterize the viable bacterial community in 234 longitudinal bronchoalveolar lavage samples from 64 lung transplant recipients and establish links to viral loads, host gene expression, lung function, and transplant health. We find that the lung microbiota post-transplant can be categorized into four distinct compositional states, ‘pneumotypes’. The predominant ‘balanced’ pneumotype is characterized by a diverse bacterial community with moderate viral loads, and host gene expression profiles suggesting immune tolerance. The other three pneumotypes are characterized by being either microbiota-depleted, or dominated by potential pathogens, and are linked to increased immune activity, lower respiratory function, and increased risks of infection and rejection. Collectively, our findings establish a link between the lung microbial ecosystem, human lung function, and clinical stability post-transplant. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-021-22344-4 |
| الإتاحة: | https://doi.org/10.1038/s41467-021-22344-4Test https://www.nature.com/articles/s41467-021-22344-4.pdfTest https://www.nature.com/articles/s41467-021-22344-4Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.B28B7B37 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-021-22344-4 |
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