دورية أكاديمية
The impact of CHOP versus bendamustine on bone mineral density in patients with indolent lymphoma enrolled in the GALLIUM study
| العنوان: | The impact of CHOP versus bendamustine on bone mineral density in patients with indolent lymphoma enrolled in the GALLIUM study |
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| المؤلفون: | Pedersen, Mette Abildgaard, Gormsen, Lars C., Jakobsen, Lasse H., Eyre, Toby A., Severinsen, Marianne T., Baech, Joachim, Dann, Eldad J., Knapp, Andrea, Sahin, Denis, Vestergaard, Peter, El-Galaly, Tarec C., Jensen, Paw |
| المصدر: | Pedersen , M A , Gormsen , L C , Jakobsen , L H , Eyre , T A , Severinsen , M T , Baech , J , Dann , E J , Knapp , A , Sahin , D , Vestergaard , P , El-Galaly , T C & Jensen , P 2024 , ' The impact of CHOP versus bendamustine on bone mineral density in patients with indolent lymphoma enrolled in the GALLIUM study ' , British Journal of Haematology , vol. 204 , no. 4 , pp. 1271-1278 . https://doi.org/10.1111/bjh.19194Test |
| سنة النشر: | 2024 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | chemotherapy, CHOP, clinical studies, late effects of therapy, non-Hodgkin lymphoma, Bone Density, Fractures, Compression/drug therapy, Humans, Middle Aged, Bendamustine Hydrochloride/adverse effects, Lymphoma, Follicular/drug therapy, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Prednisone/adverse effects, Vincristine/adverse effects, Rituximab/adverse effects, Spinal Fractures/drug therapy |
| الوصف: | Standard CHOP treatment includes a high cumulative dose of prednisone, and studies have shown increased fracture risk following CHOP. It is unclear whether reductions in bone mineral density (BMD) are caused by glucocorticoids or by the combination with chemotherapy. Our objective was to determine the effect of obinutuzumab (G)/rituximab (R)-bendamustine versus G/R-CHOP on BMD in follicular lymphoma patients. Patients in this GALLIUM post hoc study were ≥60 years old and in complete remission at induction treatment completion (ITC), following treatment with G or R in combination with bendamustine or CHOP. To assess BMD, Hounsfield units (HU) were measured in lumbar vertebra L1 on annual computed tomography. Furthermore, vertebral compression fractures were recorded. Of 173 patients included, 59 (34%) received CHOP and 114 (66%) received bendamustine. At baseline, there was no difference in HU between groups. The mean HU decrease from baseline to ITC was 27.8 after CHOP and 17.3 after bendamustine, corresponding to a difference of 10.4 (95% CI: 3.2–17.6). Vertebral fractures were recorded in 5/59 patients receiving CHOP and in 2/114 receiving bendamustine. CHOP was associated with a significant greater decrease in BMD and more frequent fractures. These results suggest that prophylaxis against BMD loss should be considered. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/0e52bb84-d887-4010-93f8-16876be6a456Test |
| DOI: | 10.1111/bjh.19194 |
| الإتاحة: | https://doi.org/10.1111/bjh.19194Test https://portal.findresearcher.sdu.dk/da/publications/0e52bb84-d887-4010-93f8-16876be6a456Test https://findresearcher.sdu.dk/ws/files/259570075/Br_J_Haematol_-_2023_-_Pedersen_-_The_impact_of_CHOP_versus_bendamustine_on_bone_mineral_density_in_patients_with_indolent.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B25B7E85 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bjh.19194 |
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