دورية أكاديمية
X-ray laser-induced ablation of lead compounds
| العنوان: | X-ray laser-induced ablation of lead compounds |
|---|---|
| المؤلفون: | Hajkova, V., Juha, L., Klinger, D., Pelka, J., Sobierajski, R., Krzywinski, J., Messerschmidt, M., Möller, S. P., Nagler, B., Rowen, M., Schlotter, W. F., Swiggers, M. L., Bohacek, P., Turner, J. J., Vinko, S. M., Whitcher, T., Wark, J., Matuchova, M., Bajt, S., Chapman, H., Dzelzainis, T., Riley, D., Andreasson, J., Burian, T., Hajdu, J., Iwan, B., Timneanu, M., Saksl, K., Fäustlin, R., Singer, A., Tiedtke, K., Toleikis, S., Vartaniants, I., Wabnitz, H., Chalupsky, J., Vysin, L., Gaudin, J., Heimann, P. A., Hau-Riege, S. P., Jurek, M. |
| المصدر: | Proceedings of SPIE 8077, 807718-1 (2011). doi:10.1117/12.890134 |
| بيانات النشر: | SPIE |
| سنة النشر: | 2011 |
| المجموعة: | DESY Publication Database (PUBDB) |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/620, Adult, Female, Hepatitis B, Chronic: complications, Humans, Interleukin 1 Receptor Antagonist Protein: genetics, Interleukin-10: genetics, Interleukin-1beta: genetics, Liver Cirrhosis: complications, Liver Cirrhosis: genetics, Male, Polymorphism, Genetic, Tumor Necrosis Factor-alpha: genetics, IL1RN protein, human, Interleukin 1 Receptor Antagonist Protein, Interleukin-1beta, Tumor Necrosis Factor-alpha, Interleukin-10 |
| جغرافية الموضوع: | DE |
| الوصف: | As liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/1996-756X; info:eu-repo/semantics/altIdentifier/pmid/pmid:17645476; info:eu-repo/semantics/altIdentifier/wos/WOS:000293212000029; info:eu-repo/semantics/altIdentifier/issn/0277-786X; https://bib-pubdb1.desy.de/record/140762Test; https://bib-pubdb1.desy.de/search?p=id:%22PHPPUBDB-24835%22Test |
| الإتاحة: | https://doi.org/10.1117/12.890134Test https://bib-pubdb1.desy.de/record/140762Test https://bib-pubdb1.desy.de/search?p=id:%22PHPPUBDB-24835%22Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B23F96B5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |