دورية أكاديمية
Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemicomplexes
| العنوان: | Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemicomplexes |
|---|---|
| المؤلفون: | Janvier Katy, Kato Yukio, Boehm Markus, Rose Jeremy R., Martina José A., Kim Bong-Yoon, Venkatesan Sundararajan, Bonifacino Juan S. |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2003 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | Adaptors, Clathrin, Coats, Endocytosis, Endosomes |
| الوصف: | 金沢大学医薬保健研究域薬学系 ; The sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present in the cytosolic tails of the proteins. A subset of these signals conform to the [DE]XXXL[LI] consensus motif and mediate sorting via interactions with heterotetrameric adaptor protein (AP) complexes. However, the identity of the AP subunits that recognize these signals remains controversial. We have used a yeast three-hybrid assay to demonstrate that [DE]XXXL[LI]-type signals from the human immunodeficiency virus negative factor protein and the lysosomal integral membrane protein II interact with combinations of the γ and σ1 subunits of AP-1 and the δ and σ3 subunits of AP-3, but not the analogous combinations of AP-2 and AP-4 subunits. The sequence requirements for these interactions are similar to those for binding to the whole AP complexes in vitro and for function of the signals in vivo. These observations reveal a novel mode of recognition of sorting signals involving the γ/δ and σ subunits of AP-1 and AP-3. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0021-9525 |
| العلاقة: | https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=15274Test; http://hdl.handle.net/2297/11864Test; Journal of Cell Biology, 163(6), 1281-1290(2003-12-22); AA00694812; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=15274&item_no=1&attribute_id=26&file_no=1Test |
| الإتاحة: | http://hdl.handle.net/2297/11864Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=15274Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=15274&item_no=1&attribute_id=26&file_no=1Test |
| رقم الانضمام: | edsbas.B1D920B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00219525 |
|---|