التفاصيل البيبلوغرافية
| العنوان: |
Prevalence and predictors of clinically significant pruritus in patients with non-alcoholic fatty liver disease (NAFLD): data from the global NASH registryâ„¢ (GNRâ„¢) |
| المؤلفون: |
Younossi, Zobair, Yilmaz, Yusuf, Yu, Ming-Ling, Isakov, Vasily, Fernandez, Marlen I. C, Wong, Vincent Wai-Sun, Eguchi, Yuichiro, Méndez-Sánchez, Nahum, Duseja, Ajay K, George, Jacob, Bugianesi, Elisabetta, Singal, Ashwani, Hamid, Saeed S, Fan, Jian-Gao, Alswat, Khalid, Papatheodoridis, George, El Kassas, Mohamed, Chan, Wah-Kheong, Gordon, Stuart C, Gomez, Manuel R, Roberts, Stuart, Lam, Brian, Younossi, Issah, Racila, Andrei, Henry, Linda, Alqahtani, Saleh, Stepanova, Maria |
| المصدر: |
Gastroenterology Meeting Abstracts |
| بيانات النشر: |
Henry Ford Health Scholarly Commons |
| سنة النشر: |
2023 |
| المجموعة: |
Henry Ford Health System Scholarly Commons |
| مصطلحات موضوعية: |
abdominal pain, adult, anxiety, clinical practice, comorbidity, conference abstract, depression, exercise, fatigue, female, fibrosis, follow up, Functional Assessment of Chronic Illness Therapy Fatigue Scale, human, liver cirrhosis, major clinical study, male, middle aged, Middle East, non insulin dependent diabetes mellitus, nonalcoholic fatty liver, nonalcoholic steatohepatitis, North Africa, obesity, outcome assessment, patient-reported outcome, prevalence, prospective study, pruritus, sleep apnea syndromes |
| الوصف: |
Background and aims: Pruritus is an important but underappreciated symptom of chronic liver diseases. We assessed factors associated with pruritus among patients with NAFLD. Method: Patients with NAFLD seen in real-world clinical practices were prospectively enrolled in the Global NAFLD/NASH Registry (GNR)™. Clinical parameters and patient reported outcomes (PROs; FACIT-F, CLDQ-NASH, WPAI) were collected. Clinically significant pruritus was defined as score ≤4 in the respective itemof CLDQ-NASH (range 1–7; lower score indicates more severe pruritus). Results:We included 4203 NAFLD subjects from 17 countries: age 52 ± 13 years, 48% male, 48% employed, 23% advanced fibrosis and 14% cirrhosis (by biopsy or non-invasive FIB-4), 44% type 2 diabetes (T2D), 21% history of depression and 45% clinically overt fatigue. Furthermore, 78% of those with a biopsy had NASH. The prevalence of clinically significant pruritus among NAFLD was 28%. The highest prevalence of significant pruritus was in patients enrolled in Middle East/North Africa and Latin America (36–39%), the lowest in South Asia (7%). NAFLD patients with pruritus were less commonly employed (42% vs. 51%), more commonly female (61% vs. 49%) and obese (69% vs 63%). Also, they more commonly had T2D (51% vs 41%), advanced fibrosis (27% vs. 22%), anxiety (47% vs. 31%), depression (30% vs 18%), fatigue (58% vs. 40%), abdominal pain (37% vs. 20%), and sleep apnea (27% vs 21%) (all p < 0.01) than those without pruritus, despite similar age (p > 0.05). NAFLD patients with pruritus experienced significantly lower PRO scores (FACIT-F, CLDQ-NASH, and WPAI) ranging from −4% to −19% of a PRO score range (all p < 0.0001) All CLDQ-NASH domain scores were lower in NAFLD patients with pruritus as compared to those without (Figure). In multivariate analysis adjusted for the regions of enrollment, independent predictors of an increased risk of pruritus included female sex, T2D, depression, clinically overt fatigue, abdominal pain, and the lack of regular ... |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://scholarlycommons.henryford.com/gastroenterology_mtgabstracts/217Test; http://sfxhosted.exlibrisgroup.com/hfhs?sid=EMBASE&issn=16000641&id=doi:10.1016%2FS0168-8278%2823%2900435-X&atitle=Prevalence+and+predictors+of+clinically+significant+pruritus+in+patients+with+non-alcoholic+fatty+liver+disease+%28NAFLD%29%3A+data+from+the+global+NASH+registry%E2%84%A2+%28GNR%E2%84%A2%29&stitle=J.+Hepatol.&title=Journal+of+Hepatology&volume=78&issue=&spage=863&epage=&aulast=Younossi&aufirst=Zobair&auinit=Z.&aufull=Younossi+Z.&coden=&isbn=&pages=863-&date=2023&auinit1=Z&auinitmTest= |
| الإتاحة: |
https://scholarlycommons.henryford.com/gastroenterology_mtgabstracts/217Test |
| رقم الانضمام: |
edsbas.B1B53A7F |
| قاعدة البيانات: |
BASE |
