دورية أكاديمية
The level of the neudesin in type-2 diabetic patients and the relationship between the metabolic parameters and carotid intima-media thickness
العنوان: | The level of the neudesin in type-2 diabetic patients and the relationship between the metabolic parameters and carotid intima-media thickness |
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المؤلفون: | Calan, M., Karatas, O., Yuksel, A., Chousein, R., Bozkaya, G., Karatas, M., Uslu, A. |
بيانات النشر: | NLM (Medline) |
سنة النشر: | 2023 |
المجموعة: | Ege University Institutional Repository |
مصطلحات موضوعية: | human, carotid intima-media thickness, insulin resistance, non insulin dependent diabetes mellitus, obesity, risk factor, Diabetes Mellitus, Type 2, Humans, Risk Factors |
الوصف: | BACKGROUND: Neudesin is a protein that is secreted from adipose tissue and central nervous system and has a regulatory function on energy metabolism. Although the effect of this protein is shown in the experimental model of type-2 diabetes mellitus (type-2DM), its effect in humans is not clearly known. In this study, we aimed to evaluate the relationship between serum neudesin level and metabolic, anthropometric and cardiovascular parameters in newly diagnosed type-2DM patients (group 1). METHODS: Forty patients in each were included in our study for group 1 and for the control group (group 2), which consisted of age and sex-matched healthy subjects. Serum neudesin, hs-CRP, carotid intima media thickness (CIMT), Body Mass Index (BMI) and insulin resistance (HOMA-IR) levels were compared prospectively. RESULTS: Serum neudesin levels were significantly higher in diabetic patients than in the control group (type-2DM: 64.69±3.06 ng/mL, control: 55.52±5.48 ng/mL, P=0.004*). There was an independent relationship between serum neudesin and HOMA-IR and BMI. Although there is a correlation between serum neudesin and CIMT; this feature disappeared in the regression analysis. CONCLUSIONS: Serum neudesin increased in new diagnosis type-2DM patients. This increase seems to be related to obesity and insulin resistance. However, more extensive research is needed to clarify this issue. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
تدمد: | 2724-6116 |
العلاقة: | Minerva endocrinology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11454/92274Test; https://doi.org/10.23736/S2724-6507.20.03217-4Test; 48; 288; 294 |
DOI: | 10.23736/S2724-6507.20.03217-4 |
الإتاحة: | https://doi.org/10.23736/S2724-6507.20.03217-4Test https://hdl.handle.net/11454/92274Test |
حقوق: | none |
رقم الانضمام: | edsbas.B189DD3 |
قاعدة البيانات: | BASE |
تدمد: | 27246116 |
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DOI: | 10.23736/S2724-6507.20.03217-4 |