دورية أكاديمية
Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism
| العنوان: | Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism |
|---|---|
| المؤلفون: | Willsey, A. Jeremy, Sanders, Stephan J., Li, Mingfeng, Dong, Shan, Tebbenkamp, Andrew T., Muhle, Rebecca A., Reilly, Steven K., Lin, Leon, Fertuzinhos, Sofia, Miller, Jeremy A., Murtha, Michael T., Bichsel, Candace, Niu, Wei, Cotney, Justin, Ercan-Sencicek, A. Gulhan, Gockley, Jake, Gupta, Abha R., Han, Wenqi, He, Xin, Hoffman, Ellen J., Klei, Lambertus, Lei, Jing, Liu, Wenzhong, Liu, Li, Lu, Cong, Xu, Xuming, Zhu, Ying, Mane, Shrikant M., Lein, Ed S., Wei, Liping, Noonan, James P., Roeder, Kathryn, Devlin, Bernie, Sestan, Nenad, State, Mat |
| المساهمون: | Devlin, B (reprint author), Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA., Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA., Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA., Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA., Yale Univ, Sch Med, Kavli Inst Neurosci, New Haven, CT 06510 USA., Peking Univ, Sch Life Sci, Ctr Bioinformat, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China., Yale Univ, Sch Med, Child Study Ctr, New Haven, CT 06510 USA., Yale Univ, Dept Computat Biol & Bioinformat, New Haven, CT 06511 USA., Allen Inst Brain Sci, Seattle, WA 98103 USA., Yale Univ, Sch Med, Program Neurogenet, New Haven, CT 06510 USA., Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA., Carnegie Mellon Univ, Ray & Stephanie Lane Ctr Computat Biol, Pittsburgh, PA 15213 USA., Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA., Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA., Yale Univ, Sch Med, Yale Ctr Genom Anal, New Haven, CT 06417 USA., Natl Inst Biol Sci, Beijing 102206, Peoples R China., Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA. |
| المصدر: | SCI |
| بيانات النشر: | cell |
| سنة النشر: | 2013 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | SPECTRUM DISORDERS, NOVO MUTATIONS, GENES, RISK, CNVS |
| الوصف: | Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology. Recent studies employing exome- and genome-wide sequencing have identified nine high-confidence ASD (hcASD) genes. Working from the hypothesis that ASD-associated mutations in these biologically pleiotropic genes will disrupt intersecting developmental processes to contribute to a common phenotype, we have attempted to identify time periods, brain regions, and cell types in which these genes converge. We have constructed coexpression networks based on the hcASD "seed'' genes, leveraging a rich expression data set encompassing multiple human brain regions across human development and into adulthood. By assessing enrichment of an independent set of probable ASD (pASD) genes, derived from the same sequencing studies, we demonstrate a key point of convergence in midfetal layer 5/6 cortical projection neurons. This approach informs when, where, and in what cell types mutations in these specific genes may be productively studied to clarify ASD pathophysiology. ; Biochemistry & Molecular Biology ; Cell Biology ; SCI(E) ; 77 ; ARTICLE ; 5 ; 997-1007 ; 155 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0092-8674 1097-4172 |
| العلاقة: | CELL.2013,155,(5),997-1007.; 808461; http://hdl.handle.net/20.500.11897/219832Test; WOS:000327500600006 |
| DOI: | 10.1016/j.cell.2013.10.020 |
| الإتاحة: | https://doi.org/20.500.11897/219832Test https://doi.org/10.1016/j.cell.2013.10.020Test https://hdl.handle.net/20.500.11897/219832Test |
| رقم الانضمام: | edsbas.B170A69B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00928674 10974172 |
|---|---|
| DOI: | 10.1016/j.cell.2013.10.020 |