دورية أكاديمية
Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis
| العنوان: | Specific targeting of inflammatory osteoclastogenesis by the probiotic yeast S. boulardii CNCM I-745 reduces bone loss in osteoporosis |
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| المؤلفون: | Madel, Maria Bernadette, Halper, Julia, Ibáñez, Lidia, Claire, Lozano, Rouleau, Matthieu, Boutin, Antoine, Mahler, Adrien, Pontier-Bres, Rodolphe, Ciucci, Thomas, Topi, Majlinda, Hue, Christophe, Amiaud, Jérôme, Iborra, Salvador, Sancho, David, Heymann, Dominique, Garchon, Henri Jean, Czerucka, Dorota, Apparailly, Florence, Duroux-Richard, Isabelle, Wakkach, Abdelilah, Blin-Wakkach, Claudine |
| المساهمون: | Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Ambroise Paré AP-HP, ANR-16-CE14-0030 Henri-Jean Garchon Henri-Jean GarchonFondation pour la Recherche Médicale ECO20160736019 Maria-Bernadette MadelAgence Nationale de la Recherche, Laboratory of Biochemistry-Hormonology, Société Française de Biologie des Tissus Minéralisés, Société Française de Rhumatol-ogie, UFR Simone Veil, Université Versailles-Saint-Quentin, Univer-sité Versailles-Saint-Quentin, National Institutes of Health, NIH, National Cancer Institute, NCI, Fondation Arthritis, American Society for Bone and Mineral Research, ASBMR, European Calcified Tissue Society, ECTS, Agence Nationale de la Recherche, ANR, (ANR-15-IDEX-01, ANR-16-CE14-0030), Fondation pour la Recherche Médicale, FRM, (ECO20160736019), Chung Hua University, CHU, (LP2M), Conseil Régional Provence-Alpes-Côte d'Azur, Société Française d'Hématologie, SFH, ANR-16-CE14-0030,ORIOS,Origine et rôle des ostéoclastes inflammatoires, nouvelles cibles thérapeutiques dans les maladies rhumatoïdes(2016) |
| المصدر: | EISSN: 2050-084X ; eLife ; https://hal.science/hal-04068580Test ; eLife, 2023, 12, ⟨10.7554/eLife.82037⟩ |
| بيانات النشر: | HAL CCSD eLife Sciences Publication |
| سنة النشر: | 2023 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Bone destruction is a hallmark of chronic inflammation, and bone-resorbing osteoclasts arising under such a condition differ from steady-state ones. However, osteoclast diversity remains poorly explored. Here, we combined transcriptomic profiling, differentiation assays and in vivo analysis in mouse to decipher specific traits for inflammatory and steady-state osteoclasts. We identified and validated the pattern-recognition receptors (PRR) Tlr2, Dectin-1, and Mincle, all involved in yeast recognition as major regulators of inflammatory osteoclasts. We showed that administration of the yeast probiotic Saccharomyces boulardii CNCM I-745 (Sb) in vivo reduced bone loss in ovariectomized but not sham mice by reducing inflammatory osteoclastogenesis. This beneficial impact of Sb is mediated by the regulation of the inflammatory environment required for the generation of inflammatory osteoclasts. We also showed that Sb derivatives as well as agonists of Tlr2, Dectin-1, and Mincle specifically inhibited directly the differentiation of inflammatory but not steady-state osteoclasts in vitro. These findings demonstrate a preferential use of the PRR-associated costimulatory differentiation pathway by inflammatory osteoclasts, thus enabling their specific inhibition, which opens new therapeutic perspectives for inflammatory bone loss. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36848406; hal-04068580; https://hal.science/hal-04068580Test; https://hal.science/hal-04068580/documentTest; https://hal.science/hal-04068580/file/elife-82037-v1.pdfTest; PUBMED: 36848406 |
| DOI: | 10.7554/eLife.82037 |
| الإتاحة: | https://doi.org/10.7554/eLife.82037Test https://hal.science/hal-04068580Test https://hal.science/hal-04068580/documentTest https://hal.science/hal-04068580/file/elife-82037-v1.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.B10F7060 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/eLife.82037 |
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