دورية أكاديمية
Interleukin-6 (IL-6) -572C-->G promoter polymorphism is associated with type 2 diabetes risk in Koreans
| العنوان: | Interleukin-6 (IL-6) -572C-->G promoter polymorphism is associated with type 2 diabetes risk in Koreans |
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| المساهمون: | Soo Jeong Koh, Yangsoo Jang, Yae Jung Hyun, Ju Yeon Park, Young Duk Song, Kyung-Kyun Shin, Jey Sook Chae, Byung-Keuk Kim, Jose M. Ordovas, Jong Ho Lee, Jang, Yang Soo |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Aged, Blood Glucose/metabolism, C-Reactive Protein/metabolism, Case-Control Studies, Diabetes Mellitus, Type 2/epidemiology, Type 2/ethnology, Type 2/genetics, Female, Genotype, Homozygote, Humans, Insulin/blood, Interleukin-6/blood, Interleukin-6/genetics, Korea, Male, Middle Aged, Polymorphism, Single Nucleotide/genetics, Promoter Regions, Genetic/genetics, Risk Factors |
| الوصف: | OBJECTIVE: Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans. SUBJECTS: A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included. MEASUREMENTS: We examined IL-6 -174G-->C, -572C-->G, -597G-->A and -1363G-->T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP). RESULTS: Homozygosity for the rare G allele IL-6 -572C-->G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C-->G genotype in control subjects (G/G: 2.33 +/- 0.41: C/G: 1.53 +/- 0.09: C/C: 1.72 +/- 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 +/- 2.9: C/G: 9.2 +/- 0.6: C/C: 7.8 +/- 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (< 0.01) and -597G-->A and -1363G-->T were monomorphic in this population. CONCLUSIONS: Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 238~244 |
| اللغة: | unknown |
| تدمد: | 0300-0664 1365-2265 |
| العلاقة: | CLINICAL ENDOCRINOLOGY; J00571; OAK-2009-00091; https://ir.ymlib.yonsei.ac.kr/handle/22282913/103431Test; T200900111; CLINICAL ENDOCRINOLOGY, Vol.70(2) : 238-244, 2009 |
| DOI: | 10.1111/j.1365-2265.2008.03315.x |
| DOI: | 10.1111/j.1365-2265.2008.03315.x/abstract |
| الإتاحة: | https://doi.org/10.1111/j.1365-2265.2008.03315.xTest https://ir.ymlib.yonsei.ac.kr/handle/22282913/103431Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.B103494F |
| قاعدة البيانات: | BASE |
| تدمد: | 03000664 13652265 |
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| DOI: | 10.1111/j.1365-2265.2008.03315.x |