دورية أكاديمية
Prognostic value of WHO grade in pancreatic neuro-endocrine tumors in Multiple Endocrine Neoplasia type 1:Results from the DutchMEN1 Study Group
| العنوان: | Prognostic value of WHO grade in pancreatic neuro-endocrine tumors in Multiple Endocrine Neoplasia type 1:Results from the DutchMEN1 Study Group |
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| المؤلفون: | Conemans, Elfi B, Brosens, Lodewijk A A, Raicu-Ionita, Gabriela M, Pieterman, Carolina R C, de Herder, Wouter W, Dekkers, Olaf M, Hermus, Ad R, van der Horst-Schrivers, Anouk N, Bisschop, Peter H, Havekes, Bas, Drent, Madeleine L, Timmers, H Th Marc, Offerhaus, G Johan, Valk, Gerlof D, Vriens, Menno R |
| المصدر: | Conemans , E B , Brosens , L A A , Raicu-Ionita , G M , Pieterman , C R C , de Herder , W W , Dekkers , O M , Hermus , A R , van der Horst-Schrivers , A N , Bisschop , P H , Havekes , B , Drent , M L , Timmers , H T M , Offerhaus , G J , Valk , G D & Vriens , M R 2017 , ' Prognostic value of WHO grade in pancreatic neuro-endocrine tumors in Multiple Endocrine Neoplasia type 1 : Results .... |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Journal Article, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | BACKGROUND: The prognostic value of WHO grade in pancreatic neuroendocrine tumors (PanNETs) in patients with Multiple Endocrine Neoplasia Type 1 (MEN1) is unknown. METHODS: We performed a cohort study using the Dutch National MEN1 database, which includes >90% of the Dutch MEN1 population with data collected between 1990 and 2014. Formalin-fixed paraffin embedded tissue blocks from the largest resected PanNET per patient were collected. MIB1 staining was performed and KI67 labeling index (LI) was determined by manual eye-counting under a microscope and by digital image analysis. Mitotic count was evaluated from hematoxylin & eosin stains. Association between WHO grade and (time until) development of liver metastases was calculated. RESULTS: Sixty-nine MEN1 patients who underwent pancreatic surgery were included. Ten patients (14%) developed liver metastases and all had PanNETs ≥3 cm. WHO G1, G2 and G3 PanNETs were seen in 83% (n = 57), 16% (n = 11) and 1% (n = 1) respectively. In non-functioning PanNETs >2 cm, liver metastases occurred in 80% of WHO G2 PanNETs (4/5) compared to 23% (5/22) in WHO G1 PanNETs (p = 0.03) when WHO grade was based on mitotic count only. This significant association was not seen for WHO grade based on Ki67 LI. After five years, liver metastases in non-functioning PanNETs were not seen in tumors ≤2 cm, in 10% of the large WHO G1 (according to mitotic count only) tumors and in 60% of large WHO G2 tumors (p-value 0.000). CONCLUSION: High mitotic count is correlated with poor prognosis in MEN1 patients with large non-functioning PanNETs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.vu.nl/en/publications/f12d6296-2889-43aa-8a68-c165894c79a0Test |
| DOI: | 10.1016/j.pan.2017.07.196 |
| الإتاحة: | https://doi.org/10.1016/j.pan.2017.07.196Test https://research.vu.nl/en/publications/f12d6296-2889-43aa-8a68-c165894c79a0Test https://hdl.handle.net/1871.1/f12d6296-2889-43aa-8a68-c165894c79a0Test https://research.vu.nl/ws/files/278076576/Prognostic_value_of_WHO_grade_in_pancreatic_neuro-endocrine_tumors_in_Multiple_Endocrine_Neoplasia_type_1.pdfTest http://www.scopus.com/inward/record.url?scp=85028301992&partnerID=8YFLogxKTest http://www.scopus.com/inward/citedby.url?scp=85028301992&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B101CE67 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.pan.2017.07.196 |
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