التفاصيل البيبلوغرافية
| العنوان: |
Functional Outcome of Intravenous Thrombolysis in Patients With Lacunar Infarcts in the WAKE-UP Trial |
| المؤلفون: |
Barow, E., Boutitie, F., Cheng, B., Cho, T. H., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Ford, I., Galinovic, I., Nickel, A., Puig, J., Roy, P., Wouters, A., Magnus, T., Thijs, V., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Gerloff, C., Thomalla, G., Golsari, A., Alegiani, A., Beck, C., Choe, C. U., Voget, D., Hoppe, J., Schroder, J., Rozanski, M., Nave, A. H., Wollboldt, C., van Sloten, I., Gohler, J., Herm, J., Jungehulsing, J., Luckl, J., Krober, J. M., Schurig, J., Koehler, L., Schlemm, L., Knops, M., Roennefarth, M., Ipsen, N., Harmel, P., Bathe-Peters, R., Fleischmann, R., Ganeshan, R., Geran, R., Hellwig, S., Schmidt, S., Tutuncu, S., Krause, T., Gramse, V., Rother, J., Michels, P., Michalski, D., Pelz, J., Schulz, A., Hobohm, C., Weise, C., Weise, G., Orthgiess, J., Pomrehn, K., Wegscheider, M., Mueller, A. K., Hennerici, M., Griebe, M., Alonso, A., Filipov, A., Marzina, A., Anders, B., Bahr, C., Hoyer, C., Schwarzbach, C., Weber, C., Hornberger, E., Pledl, H. W., Klockziem, M., Stuermlinger, M., Wittayer, M., Wolf, M., Meyer, N., Eisele, P., Steinert, S., Sauer, T., Held, V., Ringleb, P., Nagel, S., Veltkamp, R., Schwarting, S., Schwarz, A., Gumbinger, C., Hametner, C., Amiri, H., Purrucker, J., Ciatipis, M., Menn, O., Mundiyanapurath, S., Schieber, S., Kessler, T., Reiff, T., Panitz, V., Singer, O., Foerch, C., Lauer, A., Manner, A., Seiler, A., Guerzoglu, D., Schafer, J. H., Filipski, K., Lorenz, M., Kurka, N., Zeiner, P., Pfeilschifter, W., Dziewas, R., Minnerup, J., Albiker, C., Ritter, M., Seidel, M., Dittrich, R., Kallmunzer, B., Bobinger, T., Madzar, D., Stark, D., Sembill, J., Macha, K., Winder, K., Breuer, L., Koehrmann, M., Spruegel, M., Gerner, S., Moeller, S., Kraft, P., Mackenrodt, D., Kleinschnitz, C., Elhfnawy, A., Heinen, F., Gunreben, I., Poli, S., Ziemann, U., Gaenslen, A., Schlak, D., Haertig, F., Russo, F., Richter, H., Ebner, M., Ribitsch, M., Weimar, C., Zegarac, V., Chen, H. C., Althaus, K., Neugebauer, H., Juttler, E., Meier, J., Stosser, S., Puetz, V., Bodechtel, U., Ostergaard, L., Moller, A., Damgaard, D., Dupont, K. H., Poulsen, M., Hjort, N., de Morales, N. R., von Weitzel, P., Harbo, T., Marstrand, J., Hansen, A., Christensen, H., Aegidius, K., Jeppesen, L., Meden, P., Rosenbaum, S., Iversen, H., Back, C., Hansen, J., Michelsen, L., Truelsen, T., Modrau, B., Kristensen, B., Vestergaard, K., Oppel, L., Swinnen, B., Smets, I., Demeestere, J., Dobbels, L., Brouns, R., De Smedt, A., DeKeyser, J., Yperzeele, L., Van Hooff, R. J., Peeters, A., Dusart, A., Etexberria, A., Hanseeuw, B., London, F., Leempoel, J., Hohenbichler, K., Younan, N., Maqueda, V., Laloux, P., De Coene, B., De Maeseneire, C., Turine, G., Vandermeeren, Y., De Klippel, N., Willems, C., de Hollander, I., Soors, P., Hermans, S., Hemelsoet, D., Desfontaines, P., Vanacker, P., Rutgers, M., Druart, C., Paindeville, P., Peeters, D., Bruneel, B., Vancaester, E., Vanhee, F., Meersman, G., Bourgeois, P., Vanderdonckt, P., Benoit, A., Derex, L., Mechthouff, L., Berhoune, N., Ritzenthaler, T., Amarenco, P., Hobeanu, C., Gancedo, E. M., Calvet, D., Ladoux, A., Machet, A., Lamy, C., Mellerio, C., Oppenheim, C., Rodriguez-Regent, C., Bodiguel, E., Turc, G., Birchenall, J., Legrand, L., Morin, L., Edjali-Goujon, M., Naggara, O., Raphaelle, S., Godon-Hardy, S., Domigo, V., Guiraud, V., Samson, Y., Leger, A., Rosso, C., Baronnet-Chauvet, F., Crozier, S., Deltour, S., Yger, M., Sibon, I., Renou, P., Sagnier, S., Zuber, M., Tamazyan, R., Rodier, G., Morel, N., Felix, S., Vadot, W., Wolff, V., Aniculaesei, A., Yalo, B., Bindila, D., Quenardelle, V., Blanc-Lasserre, K., Landrault, E., Breynaert, L., Cakmak, S., Peysson, S., Viguier, A., Lebely, C., Raposo, N., Vallet, A. E., Vallet, P., Brugirard, S., Cheripelli, B., Kalladka, D., Moreton, F., Dani, K., El Tawil, S., Ramachandran, S., Huang, X. Y., Warburton, E., Evans, N., Perry, R., Patel, B., Cloud, G., Pereira, A., Moynihan, B., Lovelock, C., Choy, L., Khan, U., Roffe, C., Tyrell, P., Smith, C., Dixit, A., Louw, S., Broughton, D., Shetty, A., Appleton, J., Sprigg, N., Gutierrez, S. P., Acosta, B. R., van Eendenburg, C., Alcantara, J. P., Leal, J. S., Rodrigo, Mdmc, Izaga, M. T., Guillamon, O. B., Arenillas, J., Calleja, A., Cortijo, E., Mulero, P., de la Ossa, N. P., Garrido, A., Martinez, A., Esperon, C. G., Guerrero, C., Carrera, D., Vilas, D., Lopez-Cancio, E., Palomeras, E., Lucente, G., Gomis, M., Isern, I., Becerra, J. L., Vicente, J. H., Sanchez, J., Dorado, L., Grau, L., Ispierto, L., Prats, L., Almendrote, M., Hernandez, M., Jimenez, M., Sanchez, M. L., Torne, M. M., Presas, S., Ustrell, X., Pellise, A., Navalpotro, I., Luna, A., Schonewille, W., Nederkoorn, P., Majoie, C., van den Berg, L., van den Berg, S., Zonneveld, T., Remmers, M., Fazekas, F., Pichler, A., Fandler, S., Gattringer, T., Mutzenbach, J., Weber, J., Hofner, E., Kohlfurst, H., Weinstich, K., Kellert, L., Bayer-Karpinska, A., Opherk, C., Wollenweber, F., Klein, M., Neumann-Haefelin, T., Pierskalla, A., Harloff, A., Bardutzky, J., Buggle, F., von Schrader, J., Kollmar, R., Schill, J., Lobbe, A. M., Moulin, T., Bouamra, B., Bonnet, L., Touze, E., Bonnet, A. L., Cogez, J., Li, L., Guettier, S., Kar, A., Sivagnanaratham, A., Geraghty, O., Bojaryn, U., Nallasivan, A., Gonzales, M. B., Rodriguez-Yanez, M., Tembl, J., Gorriz, D., Oberndorfer, S., Prohaska, E., Blanco González, Miguel, Rodríguez Yáñez, Manuel |
| المساهمون: |
Wake-Up Investigators |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
CHUS |
| الوصف: |
Importance: The rationale for intravenous thrombolysis in patients with lacunar infarcts is debated, since it is hypothesized that the microvascular occlusion underlying lacunar infarcts might not be susceptible to pharmacological reperfusion treatment. Objective: To study the efficacy and safety of intravenous thrombolysis among patients with lacunar infarcts. Design, Setting, and Participants: This exploratory secondary post hoc analysis of the WAKE-UP trial included patients who were screened and enrolled between September 2012 and June 2017 (with final follow-up in September 2017). The WAKE-UP trial was a multicenter, double-blind, placebo-controlled randomized clinical trial to study the efficacy and safety of intravenous thrombolysis with alteplase in patients with an acute stroke of unknown onset time, guided by magnetic resonance imaging. All 503 patients randomized in the WAKE-UP trial were reviewed for lacunar infarcts. Diagnosis of lacunar infarcts was based on magnetic resonance imaging and made by consensus of 2 independent investigators blinded to clinical information. Main Outcomes and Measures: The primary efficacy variable was favorable outcome defined by a score of 0 to 1 on the modified Rankin Scale at 90 days after stroke, adjusted for age and severity of symptoms. Results: Of the 503 patients randomized in the WAKE-UP trial, 108 patients (including 74 men [68.5%]) had imaging-defined lacunar infarcts, whereas 395 patients (including 251 men [63.5%]) had nonlacunar infarcts. Patients with lacunar infarcts were younger than patients with nonlacunar infarcts (mean age [SD], 63 [12] years vs 66 [12] years; P = .003). Of patients with lacunar infarcts, 55 (50.9%) were assigned to treatment with alteplase and 53 (49.1%) to receive placebo. Treatment with alteplase was associated with higher odds of favorable outcome, with no heterogeneity of treatment outcome between lacunar and nonlacunar stroke subtypes. In patients with lacunar strokes, a favorable outcome was observed in 31 of 53 patients ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| تدمد: |
2168-6149
30907934 |
| العلاقة: |
https://jamanetwork.com/journals/jamaneurology/articlepdf/2729091/jamaneurology_barow_2019_oi_190011.pdfTest; https://www.ncbi.nlm.nih.gov/pubmed/30907934Test; http://hdl.handle.net/20.500.11940/15518Test; 31084 |
| DOI: |
10.1001/jamaneurol.2019.0351 |
| الإتاحة: |
https://doi.org/20.500.11940/15518Test
https://doi.org/10.1001/jamaneurol.2019.0351Test
https://hdl.handle.net/20.500.11940/15518Test
https://www.ncbi.nlm.nih.gov/pubmed/30907934Test |
| رقم الانضمام: |
edsbas.B0DE82D9 |
| قاعدة البيانات: |
BASE |
