دورية أكاديمية
BREG cells in Hashimoto's thyroiditis isolated or associated to further organ-specific autoimmune diseases
| العنوان: | BREG cells in Hashimoto's thyroiditis isolated or associated to further organ-specific autoimmune diseases |
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| المؤلفون: | Santaguida, Maria Giulia, Gatto, Ilenia, Mangino, Giorgio, Virili, Camilla, Stramazzo, Ilaria, Fallahi, Poupak, Antonelli, Alessandro, Segni, Maria, Romeo, Giovanna, Centanni, Marco |
| المساهمون: | Santaguida, Maria Giulia, Gatto, Ilenia, Mangino, Giorgio, Virili, Camilla, Stramazzo, Ilaria, Fallahi, Poupak, Antonelli, Alessandro, Segni, Maria, Romeo, Giovanna, Centanni, Marco |
| سنة النشر: | 2017 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Breg cell, Cellular immunity, Hashimoto's thyroiditi, Polyglandular autoimmune syndrome, Thyroid autoimmunity, ADP-ribosyl Cyclase 1, Adult, Antigens, CD19, Autoimmune Disease, B-Lymphocytes, Regulatory, CD24 Antigen, Case-Control Studie, Celiac Disease, Female, Gastritis, Atrophic, Hashimoto Disease, Human, Interleukin-10, Male, Membrane Glycoprotein, Middle Aged, Th17 Cell, Tumor Necrosis Factor Receptor Superfamily, Member 7, Vitiligo, Immunology and Allergy, Immunology |
| الوصف: | Hashimoto thyroiditis (HT) may occur isolated or associated with other non-endocrine autoimmune disorders (NEAD). No data are available about Breg cells in these disorders and this represented the aim of the study. Th17 and Breg cells subset were characterized on peripheral blood mononuclear cells isolated from 18 healthy donors (HD), 19 patients with isolated HT and 26 patients with HT + NEAD. Th17 were higher in patients with isolated HT than in HD but no further changes were seen in patients with HT + NEAD. CD24hiCD38hiunstimulated Breg cells were similar in HT patients and in HD, but significantly higher in patients with HT + NEAD than in both HT and in HD. CD19+CD24hiCD27+Breg memory phenotype was similar in HD and in HT patients, but decreased in patients with HT + NEAD (23.4%vs38.5%). Upon CpG-stimulation, CD24hiCD38hiIL-10+Breg cells were higher in HT patients than in HD (3.9%vs1.8%) but similar in patients with HT + NEAD (2.4%). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28461108; info:eu-repo/semantics/altIdentifier/wos/WOS:000414888300005; volume:184; firstpage:42; lastpage:47; numberofpages:6; journal:CLINICAL IMMUNOLOGY; http://hdl.handle.net/11568/920367Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85018985338; https://www.sciencedirect.com/science/article/pii/S152166161630568XTest |
| DOI: | 10.1016/j.clim.2017.04.012 |
| الإتاحة: | https://doi.org/10.1016/j.clim.2017.04.012Test http://hdl.handle.net/11568/920367Test https://www.sciencedirect.com/science/article/pii/S152166161630568XTest |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.B0B178C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.clim.2017.04.012 |
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