دورية أكاديمية
gga-miRNOME, a microRNA-sequencing dataset from chick embryonic tissues
| العنوان: | gga-miRNOME, a microRNA-sequencing dataset from chick embryonic tissues |
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| المؤلفون: | Duarte, Isabel, Carraco, Gil, de Azevedo, Nayara T. D., Benes, Vladimir, Andrade, Raquel P. |
| المساهمون: | Fundação para a Ciência e Tecnologia (FCT), Portugal |
| المصدر: | Scientific Data ; volume 9, issue 1 ; ISSN 2052-4463 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Library and Information Sciences, Statistics, Probability and Uncertainty, Computer Science Applications, Education, Information Systems, Statistics and Probability |
| الوصف: | MicroRNAs (miRNAs) are small non-coding RNA molecules, with sizes ranging from 18 to 25 nucleotides, which are key players in gene expression regulation. These molecules play an important role in fine-tuning early vertebrate embryo development. However, there are scarce publicly available miRNA datasets from non-mammal embryos, such as the chicken ( Gallus gallus ), which is a classical model system to study vertebrate embryogenesis. Here, we performed microRNA-sequencing to characterize the early stages of trunk and limb development in the chick embryo. For this, we profiled three chick embryonic tissues, namely, Undetermined Presomitic Mesoderm (PSM_U), Determined Presomitic Mesoderm (PSM_D) and Forelimb Distal Cyclic Domain (DCD). We identified 926 known miRNAs, and 1,141 novel candidate miRNAs, which nearly duplicates the number of Gallus gallus entries in the miRBase database. These data will greatly benefit the avian research community, particularly by highlighting new miRNAs potentially involved in the regulation of early vertebrate embryo development, that can be prioritized for further experimental testing. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41597-022-01126-7 |
| الإتاحة: | https://doi.org/10.1038/s41597-022-01126-7Test https://www.nature.com/articles/s41597-022-01126-7.pdfTest https://www.nature.com/articles/s41597-022-01126-7Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.B044C203 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41597-022-01126-7 |
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