دورية أكاديمية
Linkage Analysis of a Model Quantitative Trait in Humans: Finger Ridge Count Shows Significant Multivariate Linkage to 5q14.1
| العنوان: | Linkage Analysis of a Model Quantitative Trait in Humans: Finger Ridge Count Shows Significant Multivariate Linkage to 5q14.1 |
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| المؤلفون: | Medland, Sarah E., Loesch, Danuta Z., Mdzewski, Bogdan, Zhu, Gu, Montgomery, Grant W., Martin, Nicholas G. |
| المصدر: | Psychiatry Publications |
| بيانات النشر: | VCU Scholars Compass |
| سنة النشر: | 2007 |
| المجموعة: | Virginia Commonwealth University: VCU Scholars Compass |
| مصطلحات موضوعية: | Psychiatry and Psychology |
| الوصف: | The finger ridge count (a measure of pattern size) is one of the most heritable complex traits studied in humans and has been considered a model human polygenic trait in quantitative genetic analysis. Here, we report the results of the first genome-wide linkage scan for finger ridge count in a sample of 2,114 offspring from 922 nuclear families. Both univariate linkage to the absolute ridge count (a sum of all the ridge counts on all ten fingers), and multivariate linkage analyses of the counts on individual fingers, were conducted. The multivariate analyses yielded significant linkage to 5q14.1 (Logarithm of odds [LOD] = 3.34, pointwise-empirical p-value = 0.00025) that was predominantly driven by linkage to the ring, index, and middle fingers. The strongest univariate linkage was to 1q42.2 (LOD = 2.04, point-wise p-value = 0.002, genome-wide p-value = 0.29). In summary, the combination of univariate and multivariate results was more informative than simple univariate analyses alone. Patterns of quantitative trait loci factor loadings consistent with developmental fields were observed, and the simple pleiotropic model underlying the absolute ridge count was not sufficient to characterize the interrelationships between the ridge counts of individual fingers. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://scholarscompass.vcu.edu/psych_pubs/30Test; https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1049&context=psych_pubsTest |
| الإتاحة: | https://scholarscompass.vcu.edu/psych_pubs/30Test https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1049&context=psych_pubsTest |
| حقوق: | Copyright: © 2007 Medland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| رقم الانضمام: | edsbas.B0114F6E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |