التفاصيل البيبلوغرافية
| العنوان: |
Multi-epitope vaccine design for hepatitis E virus based on protein ORF2 and ORF3 |
| المؤلفون: |
Lu, Qiong, Wu, Hao, Meng, Jing, Wang, Jiangyuan, Wu, Jiajing, Liu, Shuo, Tong, Jincheng, Nie, Jianhui, Huang, Weijin |
| المصدر: |
Frontiers in Microbiology ; volume 15 ; ISSN 1664-302X |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2024 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Microbiology (medical), Microbiology |
| الوصف: |
Introduction Hepatitis E virus (HEV), with heightened virulence in immunocompromised individuals and pregnant women, is a pervasive threat in developing countries. A globaly available vaccine against HEV is currently lacking. Methods We designed a multi-epitope vaccine based on protein ORF2 and ORF3 of HEV using immunoinformatics. Results The vaccine comprised 23 nontoxic, nonallergenic, soluble peptides. The stability of the docked peptide vaccine-TLR3 complex was validated by molecular dynamic simulations. The induction of effective cellular and humoral immune responses by the multi-peptide vaccine was verified by simulated immunization. Discussion These findings provide a foundation for future HEV vaccine studies. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fmicb.2024.1372069 |
| DOI: |
10.3389/fmicb.2024.1372069/full |
| الإتاحة: |
https://doi.org/10.3389/fmicb.2024.1372069Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.AFF038CB |
| قاعدة البيانات: |
BASE |
