التفاصيل البيبلوغرافية
| العنوان: |
The influence of body mass index on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in women with early-stage breast cancer |
| المؤلفون: |
Lin, Lishi, Soesan, Marcel, van Balen, Dorieke E M, Beijnen, Jos H, Huitema, Alwin D R |
| المساهمون: |
Apotheek O&O&O, Cancer |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Body mass index, Breast cancer, Chemotherapy, Obesity, Paclitaxel, Relative dose intensity, Oncology, Cancer Research |
| الوصف: |
Purpose: To investigate the influence of body mass index (BMI) on the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy in early breast cancer patients. Methods: Early-stage breast cancer patients who received (neo)adjuvant weekly paclitaxel 80 mg/m 2 chemotherapy were included in this retrospective study. Patients were divided into three groups based on their BMI: lean, overweight, and obese. Logistic regression was used to assess for association between BMI with administered relative dose intensity (RDI) < 85%. The occurrence of treatment modifications and the pathological response on neoadjuvant chemotherapy were compared between BMI categories. Results: Four hundred (400) patients were included in this study; 200 (50%) lean, 125 (31%) overweight, and 75 (19%) obese patients. The adjusted odds ratio to receive RDI < 85% for BMI was 1.02 (p value,.263). Treatment modifications occurred in 115 (58%), 82 (66%), and 52 (69%) patients in the respective BMI categories (p value =.132). Peripheral neuropathy was observed in 79 (40%), 58 (46%), and 41 (55%) patients in the lean, overweight, and obese group (p value =.069), whereas hematologic toxicity was observed in 31 (16%), 10 (8%), and 4 (5%) patients (p value =.025). Pathological complete response was observed in 22 (17%), 11 (14%), and 6 (13%) patients in the respective BMI categories (p value =.799). Conclusion: BMI did not significantly influence the tolerability and effectiveness of full-weight-based paclitaxel chemotherapy. Therefore, the results of this study align with current guideline recommendations of using full-weight-based paclitaxel chemotherapy in obese patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0167-6806 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/448200Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/448200Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.AF93623 |
| قاعدة البيانات: |
BASE |
