دورية أكاديمية
suPAR level is associated with myocardial impairment assessed with advanced echocardiography in patients with type 1 diabetes with normal ejection fraction and without known heart disease or end-stage renal disease
| العنوان: | suPAR level is associated with myocardial impairment assessed with advanced echocardiography in patients with type 1 diabetes with normal ejection fraction and without known heart disease or end-stage renal disease |
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| المؤلفون: | Theilade, Simone, Rossing, Peter, Eugen-Olsen, Jesper, Jensen, Jan S, Jensen, Magnus T |
| المصدر: | Theilade , S , Rossing , P , Eugen-Olsen , J , Jensen , J S & Jensen , M T 2016 , ' suPAR level is associated with myocardial impairment assessed with advanced echocardiography in patients with type 1 diabetes with normal ejection fraction and without known heart disease or end-stage renal disease ' , European Journal of Endocrinology , vol. 174 , no. 6 , pp. 745-53 . https://doi.org/10.1530/EJE-15-0986Test |
| سنة النشر: | 2016 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Adult, Aged, Diabetes Mellitus, Type 1, Echocardiography, Female, Heart, Humans, Kidney Failure, Chronic, Male, Middle Aged, Receptors, Urokinase Plasminogen Activator, Risk Factors, Ventricular Dysfunction, Left, Journal Article |
| الوصف: | AIM: Heart disease is a common fatal diabetes-related complication. Early detection of patients at particular risk of heart disease is of prime importance. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker for development of cardiovascular disease. We investigate if suPAR is associated with early myocardial impairment assessed with advanced echocardiographic methods. METHODS: In an observational study on 318 patients with type 1 diabetes without known heart disease and with normal left ventricular ejection fraction (LVEF) (biplane LVEF >45%), we performed conventional, tissue Doppler and speckle tracking echocardiography, and measured plasma suPAR levels. Associations between myocardial function and suPAR levels were studied in adjusted models including significant covariates. RESULTS: Patients were 55±12 years (mean±s.d.) and 160 (50%) males. Median (interquartile range) suPAR was 3.4 (1.7) ng/mL and LVEF was 58±5%. suPAR levels were not associated with LVEF (P=0.11). In adjusted models, higher suPAR levels were independently associated with both impaired systolic function assessed with global longitudinal strain (GLS) and tissue velocity s', and with impaired diastolic measures a' and e'/a' (all P=0.034). In multivariable analysis including cardiovascular risk factors and both systolic and diastolic measures (GLS and e'/a'), both remained independently associated with suPAR levels (P=0.012). CONCLUSIONS: In patients with type 1 diabetes with normal LVEF and without known heart disease, suPAR is associated with early systolic and diastolic myocardial impairment. Our study implies that both suPAR and advanced echocardiography are useful diagnostic tools for identifying patients with diabetes at risk of future clinical heart disease, suited for intensified medical therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1530/EJE-15-0986 |
| الإتاحة: | https://doi.org/10.1530/EJE-15-0986Test https://curis.ku.dk/portal/da/publications/supar-level-is-associated-with-myocardial-impairment-assessed-with-advanced-echocardiography-in-patients-with-type-1-diabetes-with-normal-ejection-fraction-and-without-known-heart-disease-or-endstage-renal-diseaseTest(76f143ca-d7e0-42fa-976a-c7704667d102).html |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.AF40D0D2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/EJE-15-0986 |
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