التفاصيل البيبلوغرافية
| العنوان: |
A Novel Classification Model for Lower-Grade Glioma Patients Based on Pyroptosis-Related Genes |
| المؤلفون: |
Yusheng Shen, Hao Chi, Ke Xu, Yandong Li, Xisheng Yin, Shi Chen, Qian Yang, Miao He, Guohua Zhu, Xiaosong Li |
| المصدر: |
Brain Sciences; Volume 12; Issue 6; Pages: 700 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
lower-grade glioma, pyroptosis, immunotherapy, targeted therapy |
| الوصف: |
Recent studies demonstrated that pyroptosis plays a crucial role in shaping the tumor-immune microenvironment. However, the influence of pyroptosis on lower-grade glioma regarding immunotherapy and targeted therapy is still unknown. This study analyzed the variations of 33 pyroptosis-related genes in lower-grade glioma and normal tissues. Our study found considerable genetic and expression alterations in heterogeneity among lower-grade gliomas and normal brain tissues. There are two pyroptosis phenotypes in lower-grade glioma, and they exhibited differences in cell infiltration characteristics and clinical characters. Then, a PyroScore model using the lasso-cox method was constructed to measure the level of pyroptosis in each patient. PyroScore can refine the lower-grade glioma patients with a stratified prognosis and a distinct tumor immune microenvironment. Pyscore may also be an effective factor in predicting potential therapeutic benefits. In silico analysis showed that patients with a lower PyroScore are expected to be more sensitive to targeted therapy and immunotherapy. These findings may enhance our understanding of pyroptosis in lower-grade glioma and might help optimize risk stratification for the survival and personalized management of lower-grade glioma patients. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular and Cellular Neuroscience; https://dx.doi.org/10.3390/brainsci12060700Test |
| DOI: |
10.3390/brainsci12060700 |
| الإتاحة: |
https://doi.org/10.3390/brainsci12060700Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.AF3DCAA1 |
| قاعدة البيانات: |
BASE |
