دورية أكاديمية
Neurovascular Interface in Porcine Small Intestine: Specific for Nitrergic rather than Nonnitrergic Neurons
| العنوان: | Neurovascular Interface in Porcine Small Intestine: Specific for Nitrergic rather than Nonnitrergic Neurons |
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| المؤلفون: | Jabari, Samir, Neuhuber, Winfried, Brehmer, Axel |
| سنة النشر: | 2016 |
| المجموعة: | OPUS FAU - Online publication system of Friedrich-Alexander-Universität Erlangen-Nürnberg |
| مصطلحات موضوعية: | ddc:611 |
| الوصف: | In the 1970s, by using classic histological methods, close topographical relationships between special areas of enteric ganglia and capillaries were shown in the pig. In this study, by application of double and triple immunohistochemistry, we confirmed this neurovascular interface and demonstrated that these zones are mainly confined to nitrergic neurons in the myenteric and the external submucosal plexus. In the upper small intestine of the pig, the respective neurons display type III morphology, i.e. they have long, slender and branched dendrites and a single axon. In another set of experiments, we prepared specimens for electron-microscopical analysis of these zones. Both ganglia and capillaries display continuous basement membranes, the smallest distances between them being 1,000 nm at the myenteric and 300 nm at the external submucosal level. The capillary endothelium was mostly continuous but, at the external submucosal level, scattered fenestrations were observed. This particular neurovascular relationship suggests that nitrergic neurons may require a greater amount of oxygen and/or nutrients. In guinea pig and mouse, previous ischemia/reperfusion experiments showed that nitrergic neurons are selectively damaged. Thus, a preferential blood supply of enteric nitrergic neurons may indicate that these neurons are more vulnerable in ischemia. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/10776Test; urn:nbn:de:bvb:29-opus4-107766; https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-107766Test; https://doi.org/10.1159/000444168Test; https://opus4.kobv.de/opus4-fau/files/10776/CTO444168.pdfTest |
| DOI: | 10.1159/000444168 |
| الإتاحة: | https://doi.org/10.1159/000444168Test https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/10776Test https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-107766Test https://opus4.kobv.de/opus4-fau/files/10776/CTO444168.pdfTest |
| حقوق: | http://www.gesetze-im-internet.de/urhg/index.htmlTest ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AF18E57B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000444168 |
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