دورية أكاديمية
Successive Onset of Molecular, Cellular and Tissue-Specific Responses in Midgut Gland of Littorina littorea Exposed to Sub-Lethal Cadmium Concentrations
| العنوان: | Successive Onset of Molecular, Cellular and Tissue-Specific Responses in Midgut Gland of Littorina littorea Exposed to Sub-Lethal Cadmium Concentrations |
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| المؤلفون: | Benito Fernández, Denis, Niederwanger, Michael, Izaguirre Aramayona, Urtzi, Dallinger, Reinhard, Soto López, Manuel |
| بيانات النشر: | MDPI |
| سنة النشر: | 2017 |
| المجموعة: | ADDI: Repositorio Institucional de la Universidad del País Vasco / Euskal Herriko Unibertsitatea (UPV/EHU - Basque Country University) |
| مصطلحات موضوعية: | littorina littorea, metallothionein induction, midgut gland tubules, digestive cells, basophilic cells, connective tissue calcium cells, lysosomes, lipofuscin, ray microprobe analysis, digestive gland, subcellular-distribution, quantitative alterations, lysosomal structure, level biomarkers, oxidative stress, marine organisms, mytilus-edulis, helix-pomatia |
| الوصف: | Cadmium (Cd) is one of the most harmful metals, being toxic to most animal species, including marine invertebrates. Among marine gastropods, the periwinkle (Littorina littorea) in particular can accumulate high amounts of Cd in its midgut gland. In this organ, the metal can elicit extensive cytological and tissue-specific alterations that may reach, depending on the intensity of Cd exposure, from reversible lesions to pathological cellular disruptions. At the same time, Littorina littorea expresses a Cd-specific metallothionein (MT) that, due to its molecular features, expectedly exerts a protective function against the adverse intracellular effects of this metal. The aim of the present study was, therefore, to assess the time course of MT induction in the periwinkle's midgut gland on the one hand, and cellular and tissue-specific alterations in the digestive organ complex (midgut gland and digestive tract) on the other, upon exposure to sub-lethal Cd concentrations (0.25 and 1 mg Cd/L) over 21 days. Depending on the Cd concentrations applied, the beginning of alterations of the assessed parameters followed distinct concentration-dependent and time-dependent patterns, where the timeframe for the onset of the different response reactions became narrower at higher Cd concentrations compared to lower exposure concentrations. ; This work was funded by the Austrian Science foundation (FWF) Project ref. I 1482-N28 (DACH) granted to Reinhard Dallinger. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | http://www.mdpi.com/1422-0067/18/8/1815Test; International Journal of Molecular Sciences 18(8) : (2017) // Article ID 1815; http://hdl.handle.net/10810/27254Test |
| DOI: | 10.3390/ijms18081815 |
| الإتاحة: | https://doi.org/10.3390/ijms18081815Test http://hdl.handle.net/10810/27254Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/3.0/esTest/ ; © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0Test/). ; Atribución 3.0 España |
| رقم الانضمام: | edsbas.AEC369AD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms18081815 |