دورية أكاديمية
Somatic evolution and global expansion of an ancient transmissible cancer lineage
| العنوان: | Somatic evolution and global expansion of an ancient transmissible cancer lineage |
|---|---|
| المؤلفون: | Baez-Ortega A., Gori K., Strakova A., Allen J.L., Allum K.M., Bansse-Issa L., Bhutia T.N., Bisson J.L., Briceño C., Domracheva A.C., Corrigan A.M., Cran H.R., Crawford J.T., Davis E., De Castro K.F., De Nardi A.B., De Vos A.P., Keenan L.D., Donelan E.M., Espinoza Huerta A.R., Faramade I.A., Fazil M., Fotopoulou E., Fruean S.N., Gallardo-Arrieta F., Glebova O., Gouletsou P.G., Häfelin Manrique R.F., Henriques J.J.G.P., Horta R.S., Ignatenko N., Kane Y., King C., Koenig D., Krupa A., Kruzeniski S.J., Kwon Y.-M., Lanza-Perea M., Lazyan M., Lopez Quintana A.M., Losfelt T., Marino G., Castañeda S.M., Martínez-López M.F., Meyer M., Migneco E.J., Nakanwagi B., Neal K.B., Neunzig W., Leathlobhair M.N., Nixon S.J., Ortega-Pacheco A., Pedraza-Ordoñez F., Peleteiro M.C., Polak K., Pye R.J., Reece J.F., Gutierrez J.R., Sadia H., Schmeling S.K., Shamanova O., Sherlock A.G., Stammnitz M., Steenland-Smit A.E., Svitich A., Tapia Martínez L.J., Ngoka I.T., Torres C.G., Tudor E.M., Van Der Wel M.G., Viţălaru B.A., Vural S.A., Walkinton O., Wang J., Wehrle-Martinez A.S., Widdowson S.A.E., Stratton M.R., Alexandrov L.B., Martincorena I., Murchison E.P. |
| المصدر: | Science ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071029662&doi=10.1126%2fscience.aau9923&partnerID=40&md5=8f5c9f8d910e3a0fb6b5b67bf7f4d067Test |
| سنة النشر: | 2019 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | double stranded DNA, mitochondrial DNA, cancer, genetic drift, mutation, phylogeny, phylogeography, tumor, ultraviolet radiation, animal venereal tumor, Article, canine transmissible venereal tumor, disease transmission, DNA damage, gene expression, genetic variability, genomic instability, malignant neoplasm, mutational analysis, nonhuman, nonsense mutation, phylogenetic tree, priority journal, somatic mutation, whole exome sequencing, animal, classification, clonal evolution, dog, dog disease |
| الوصف: | The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by “metastasizing” between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution. © 2019 American Association for the Advancement of Science. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 00368075 |
| العلاقة: | http://hdl.handle.net/11615/71038Test |
| DOI: | 10.1126/science.aau9923 |
| الإتاحة: | https://doi.org/10.1126/science.aau9923Test http://hdl.handle.net/11615/71038Test |
| رقم الانضمام: | edsbas.AE721ED3 |
| قاعدة البيانات: | BASE |
| تدمد: | 00368075 |
|---|---|
| DOI: | 10.1126/science.aau9923 |