دورية أكاديمية
Gonadotropic status in adult women with pituitary stalk interruption syndrome ; Gonadotropic status in adult women with pituitary stalk interruption syndrome: Gonadotropic function in adult women with PSIS
| العنوان: | Gonadotropic status in adult women with pituitary stalk interruption syndrome ; Gonadotropic status in adult women with pituitary stalk interruption syndrome: Gonadotropic function in adult women with PSIS |
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| المؤلفون: | Terray, A, Baussart, B, Zins, M, Goldberg, M, Kab, S, Cazabat, L, Briere, M, Brue, T, Barraud, S, Reznik, Y, Christin Maitre, S, Illouz, F, Raverot, G, Young, J, Raffin-Sanson, M, L, Hage, Mirella |
| المساهمون: | Hôpital Ambroise Paré AP-HP, Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (BECCOH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Foch Suresnes, Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Marseille Maladies Rares (MarMaRa), Aix Marseille Université (AMU), Service d'endocrinologie, diabète, maladies métaboliques Hôpital de la Conception - APHM, Hôpital universitaire Robert Debré Reims (CHU Reims), Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Hôpital Côte de Nacre CHU Caen, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Saint-Antoine AP-HP, Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université d'Angers (UA), Groupement Hospitalier Lyon-Est (GHE), Hospices Civils de Lyon (HCL), Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Physiologie et physiopathologie endocriniennes (PHYSENDO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, This work was supported by the French reference center for rare pituitary diseases HYPO, which is funded by the French Ministry of Health through Assistance Publique – Hôpitaux de Marseille and by the National Research Agency (ANR-11-INBS-0002) Grant for the CONSTANCES cohort., ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011) |
| المصدر: | ISSN: 0804-4643. |
| بيانات النشر: | HAL CCSD Oxford Univ. Press |
| سنة النشر: | 2024 |
| المجموعة: | Hospices Civils de Lyon (HCL): HAL |
| مصطلحات موضوعية: | hypopituitarism, fertility, ovulation induction, panhypopituitarism, assisted reproductive techniques, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism |
| الوصف: | International audience ; Objective Pituitary stalk interruption syndrome (PSIS) is a rare cause of congenital hypopituitarism. Limited data exist on the gonadotropic status and fertility of adult women with PSIS. Our study aims to describe pubertal development and the evolution of gonadotropic function and fertility in adult women with PSIS. Design Retrospective multicentric French study. MethodsWe described gonadotropic function in 56 adult women with PSIS from puberty onwards. We compared live birth rates per woman with PSIS to age-matched controls from the large French epidemiological cohort (CONSTANCES). Additionally, we assessed height, BMI, blood pressure, other metabolic parameters, and socio-economic status. Results and ConclusionsAmong 56 women with PSIS, 36 did not experience spontaneous puberty. Of these, 13 underwent ovarian stimulation resulting in 7 women having a total of 11 children. In the subgroup with spontaneous puberty (n = 20), 4 had a total of 8 pregnancies while 6 developed secondary gonadotropic deficiency. Women with PSIS had fewer children than controls (0.33 versus 0.63, p = 0.04). Median height was also lower (160.5 cm versus 165.0 cm, p < 0.0001). Although mean blood pressure was lower in women with PSIS compared to controls, (111.3/65.9 ± 11.2/8.1 mmHg vs 118.7/72.1 ± 10.1/7.7 mmHg, p < 0.001), there were no significant differences in other metabolic parameters, notably BMI and lipid profile. Employment/academic status was not different in the two groups but fewer women with PSIS were in relationships (42% versus 57.6% in controls, p = 0.02). The fertility prognosis in patients with PSIS needs optimization. Patients should be informed about the likelihood of declining gonadotropic function over time. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38857190; hal-04609641; https://amu.hal.science/hal-04609641Test; https://amu.hal.science/hal-04609641/documentTest; https://amu.hal.science/hal-04609641/file/Terray%202024%20EJE%20accepted%20MS_Gonadotrope%20status%20PSIS%201.pdfTest; PUBMED: 38857190 |
| DOI: | 10.1093/ejendo/lvae064 |
| الإتاحة: | https://doi.org/10.1093/ejendo/lvae064Test https://amu.hal.science/hal-04609641Test https://amu.hal.science/hal-04609641/documentTest https://amu.hal.science/hal-04609641/file/Terray%202024%20EJE%20accepted%20MS_Gonadotrope%20status%20PSIS%201.pdfTest |
| رقم الانضمام: | edsbas.ADF863BF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ejendo/lvae064 |
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