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DREIMT: a drug repositioning database and prioritization tool for immunomodulation.

التفاصيل البيبلوغرافية
العنوان: DREIMT: a drug repositioning database and prioritization tool for immunomodulation.
المؤلفون: Troulé, Kevin, López-Fernández, Hugo, García-Martín, Santiago, Reboiro-Jato, Miguel, Carretero-Puche, Carlos, Martorell-Marugán, Jordi, Martín-Serrano, Guillermo, Carmona-Sáez, Pedro, Glez-Peña, Daniel, Al-Shahrour, Fátima, Gómez-López, Gonzalo
سنة النشر: 2021
المجموعة: Sistema Sanitario Público de Andalucía (SSPA): Repositorio
مصطلحات موضوعية: Databases, Factual, Pharmaceutical, Drug Repositioning, Immunomodulation, Transcriptome
الوصف: Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and ∼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables. http://www.dreimt.orgTest. Supplementary data are available at Bioinformatics online.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 32818254
1367-4811
العلاقة: http://hdl.handle.net/10668/16121Test; https://academic.oup.com/bioinformatics/article-pdf/37/4/578/37757681/btaa727.pdfTest
DOI: 10.1093/bioinformatics/btaa727
الإتاحة: https://doi.org/10.1093/bioinformatics/btaa727Test
http://hdl.handle.net/10668/16121Test
https://academic.oup.com/bioinformatics/article-pdf/37/4/578/37757681/btaa727.pdfTest
حقوق: open access
رقم الانضمام: edsbas.ADF7B9CD
قاعدة البيانات: BASE
الوصف
تدمد:32818254
13674811
DOI:10.1093/bioinformatics/btaa727