دورية أكاديمية
Nonalcoholic fatty liver disease and risk of incident young-onset hypertension: effect modification by sex
| العنوان: | Nonalcoholic fatty liver disease and risk of incident young-onset hypertension: effect modification by sex |
|---|---|
| المؤلفون: | Kim, Yejin, Chang, Yoosoo, Ryu, Seungho, Park, Soyoung, Cho, Yoosun, Sohn, Won, Kang, Jeonggyu, Wild, Sarah H., Byrne, Christopher |
| سنة النشر: | 2023 |
| المجموعة: | University of Southampton: e-Prints Soton |
| الوصف: | Background and aims: Although nonalcoholic fatty liver disease (NAFLD) and hypertension are increasingly common among young adults, it is uncertain if NAFLD affects incidence of young-onset hypertension, and if the association is modified by sex. We investigated potential effect modification by sex on the association between NAFLD and incident hypertension in young adults (<40 years). Method and results: This cohort study comprised 85,789 women and 67,553 men aged <40 years without hypertension at baseline. Hepatic steatosis was assessed by liver ultrasound and classified as mild or moderate/severe. Hypertension was defined as blood pressure (BP) ≥130/80 mmHg; self-reported history of physician-diagnosed hypertension; or current use of BP-lowering medications. Cox proportional hazard models were used to estimate hazard ratios (HRs; 95% confidence intervals [CIs]) for incident hypertension by NAFLD status (median follow-up 4.5 years). A total of 25,891 participants developed incident hypertension (incidence rates per 10 3 person-years: 15.6 for women and 63.5 for men). Multivariable-adjusted HRs (95% CIs) for incident hypertension comparing no NAFLD (reference) with mild or moderate/severe NAFLD were 1.68 (1.56–1.80) and 1.83 (1.60–2.09) for women and 1.21 (1.17–1.25) and 1.23 (1.17–1.30) for men, respectively. Stronger associations were consistently observed between NAFLD and incident hypertension in women, regardless of obesity/central obesity (all p-values for interaction by sex <0.001). Conclusions: NAFLD is a potential risk factor for young-onset hypertension with a relatively greater impact in women and in those with more severe hepatic steatosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text; image |
| اللغة: | English |
| العلاقة: | https://eprints.soton.ac.uk/477673/1/NMCD_D_23_00312_R1_Manuscript_clean.pdfTest; https://eprints.soton.ac.uk/477673/2/NMCD_D_23_00312_R1_Highlights.pdfTest; https://eprints.soton.ac.uk/477673/3/NMCD_D_23_00312_R1_Supplementary_Materials.pdfTest; https://eprints.soton.ac.uk/477673/4/NMCD_D_23_00312_R1_Figure_1.tifTest; https://eprints.soton.ac.uk/477673/5/NMCD_D_23_00312_R1_Graphical_Abstract.tifTest; Kim, Yejin, Chang, Yoosoo, Ryu, Seungho, Park, Soyoung, Cho, Yoosun, Sohn, Won, Kang, Jeonggyu, Wild, Sarah H. and Byrne, Christopher (2023) Nonalcoholic fatty liver disease and risk of incident young-onset hypertension: effect modification by sex. Nutrition, Metabolism & Cardiovascular Diseases, 33 (8), 1608-1616. (doi:10.1016/j.numecd.2023.04.021 ). |
| الإتاحة: | https://eprints.soton.ac.uk/477673Test/ https://eprints.soton.ac.uk/477673/1/NMCD_D_23_00312_R1_Manuscript_clean.pdfTest https://eprints.soton.ac.uk/477673/2/NMCD_D_23_00312_R1_Highlights.pdfTest https://eprints.soton.ac.uk/477673/3/NMCD_D_23_00312_R1_Supplementary_Materials.pdfTest https://eprints.soton.ac.uk/477673/4/NMCD_D_23_00312_R1_Figure_1.tifTest https://eprints.soton.ac.uk/477673/5/NMCD_D_23_00312_R1_Graphical_Abstract.tifTest |
| حقوق: | cc_by_nc_nd_4 |
| رقم الانضمام: | edsbas.AD9C883A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |