دورية أكاديمية
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial.
| العنوان: | Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. |
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| المؤلفون: | Wherrett, Diane K, Bundy, Brian, Becker, Dorothy J, DiMeglio, Linda A, Gitelman, Stephen E, Goland, Robin, Gottlieb, Peter A, Greenbaum, Carla J, Herold, Kevan C, Marks, Jennifer B, Monzavi, Roshanak, Moran, Antoinette, Orban, Tihamer, Palmer, Jerry P, Raskin, Philip, Rodriguez, Henry, Schatz, Desmond, Wilson, Darrell M, Krischer, Jeffrey P, Skyler, Jay S |
| المصدر: | Lancet ; ISSN:1474-547X ; Volume:378 ; Issue:9788 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2011 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Glutamic acid decarboxylase (GAD) is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. In animal models of autoimmunity, treatment with a target antigen can modulate aggressive autoimmunity. We aimed to assess whether immunisation with GAD formulated with aluminum hydroxide (GAD-alum) would preserve insulin production in recent-onset type 1 diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/S0140-6736Test(11)60895-7; https://pubmed.ncbi.nlm.nih.gov/21714999Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580128Test/ |
| DOI: | 10.1016/S0140-6736(11)60895-7 |
| الإتاحة: | https://doi.org/10.1016/S0140-6736Test(11)60895-7 https://pubmed.ncbi.nlm.nih.gov/21714999Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580128Test/ |
| حقوق: | Copyright © 2011 Elsevier Ltd. All rights reserved. |
| رقم الانضمام: | edsbas.AD8BD7F0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S0140-6736(11)60895-7 |
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