دورية أكاديمية
Presence and Expression of Human Herpesvirus 6 in Peripheral Blood Mononuclear Cells of S100-Positive, T Cell Chronic Lymphoproliferative Disease
| العنوان: | Presence and Expression of Human Herpesvirus 6 in Peripheral Blood Mononuclear Cells of S100-Positive, T Cell Chronic Lymphoproliferative Disease |
|---|---|
| المؤلفون: | Braun, Daniel K., Pellett, Philip E., Hanson, Curtis A. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1995 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Concise Communications |
| الوصف: | S100-positive, T cell chronic lymphoproliferative disease (S100-CLPD) is a rare and aggressive hematologic disorder in which the cytoplasmic protein S100 is expressed at high levels in abnormal lymphocytes. Using a DNA probe specific for human herpesvirus 6 (HHV-6), 2 cases of S100-CLPD were examined by DNA and RNA hybridization analysis. The results indicated that HHV-6 DNA was present in uncultured peripheral blood mononuclear cells (PBMC) and that a 1.3-kb viral transcript was expressed in both cases. Analysis of flow-sorted PBMC from 1 case demonstrated that HHV-6 DNA was present exclusively in the S100-positive fraction. Studies using other HHV-6 DNA probes suggested infection with HHV-6 variant B in both cases. Hybridization studies using DNA from PBMC of 27 cases of T cell chronic lymphoproliferative disease of other types showed no evidence of HHV-6. These studies suggest a possible specific association of HHV-6 with the unusual disorder S100-CLPD. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://jid.oxfordjournals.org/cgi/content/short/171/5/1351Test; http://dx.doi.org/10.1093/infdis/171.5.1351Test |
| DOI: | 10.1093/infdis/171.5.1351 |
| الإتاحة: | https://doi.org/10.1093/infdis/171.5.1351Test http://jid.oxfordjournals.org/cgi/content/short/171/5/1351Test |
| حقوق: | Copyright (C) 1995, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.AD766B8C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/171.5.1351 |
|---|