دورية أكاديمية
Leptin and IGF-1 in Infancy Are Associated With Variants in DHCR7 and CYP2R1 That Relate With Type 1 Diabetes and 25OHD.
| العنوان: | Leptin and IGF-1 in Infancy Are Associated With Variants in DHCR7 and CYP2R1 That Relate With Type 1 Diabetes and 25OHD. |
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| المؤلفون: | Eleftheriou, Antigoni, Ong, Ken K, Hughes, Ieuan A, Petry, Clive J |
| بيانات النشر: | Department of Clinical Biochemistry //dx.doi.org/10.1210/clinem/dgad263 J Clin Endocrinol Metab The Endocrine Society |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | IGF-1, early growth, leptin, type 1 diabetes, vitamin D, Infant, Newborn, Male, Female, Humans, Child, Preschool, Cholestanetriol 26-Monooxygenase, Diabetes Mellitus, Type 1, Insulin-Like Growth Factor I, Prospective Studies, Cytochrome P450 Family 2, Vitamins, Polymorphism, Single Nucleotide, Genotype, Vitamin D Deficiency, Genetic Predisposition to Disease |
| الوصف: | CONTEXT: Vitamin D has been variably implicated in risk of developing type 1 diabetes based on cohorts of at-risk individuals. Emergent type 1 diabetes in childhood is putatively preceded by altered growth. OBJECTIVE: We explored whether polymorphisms in vitamin D metabolism genes modify risk of type 1 diabetes via effects on growth in a prospective, population-based cohort of infants. METHODS: The Cambridge Baby Growth Study enrolled newborns from Cambridgeshire, UK, for follow-up in infancy. In 612 infants, we genotyped single nucleotide polymorphisms in vitamin D metabolism genes that relate with type 1 diabetes: rs10741657 and rs12794714 in CYP2R1, rs12785878 in DHCR7, and rs10877012 in CYP27B1. Multivariate linear regression analyses tested associations between genotypes and anthropometric indices (weight, length, and skinfold thickness) or growth-related hormones (C-peptide, IGF-1, and leptin) in infancy. RESULTS: Birth weight showed borderline associations with the diabetes risk-increasing alleles in CYP2R1, rs10741657 (β = -.11, P = .02) and rs12794714 (β = -.09, P = .04). The risk-increasing allele rs12794714 was also associated with higher IGF-1 levels at age 24 months (β = .30, P = .01). At age 3 months, the risk-increasing allele rs12785878 in DHCR7, known to negatively associate with 25-hydroxyvitamin D levels, showed a positive association with leptin levels (β = .23, P = .009), which was pronounced in girls (P = .004) vs boys (P = .7). CONCLUSION: The vitamin D metabolism genes DHCR7 and CYP2R1 might influence infancy leptin and IGF-1 levels respectively. These findings open the possibility for a developmental role of vitamin D that is mediated by growth-related hormones with implications for the onset of type 1 diabetes autoimmunity. ; This work was supported by the Medical Research Council [MR/K50127X/1] and the Raymond & Beverly Sackler Foundation. The CBGS has been funded by the European Union Framework 5 [QLK4-1999-01422]; the Medical Research Council [7500001180, G1001995, U106179472]; ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/msword |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17863/CAM.92913Test; https://www.repository.cam.ac.uk/handle/1810/349647Test; https://doi.org/10.17863/CAM.96591Test |
| DOI: | 10.17863/CAM.96591 |
| الإتاحة: | https://doi.org/10.17863/CAM.96591Test https://doi.org/10.17863/CAM.92913Test https://www.repository.cam.ac.uk/handle/1810/349647Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.AD347C36 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.96591 |
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