دورية أكاديمية
Association of oxytocin augmentation and duration of labour with postpartum haemorrhage: A cohort study of nulliparous women
| العنوان: | Association of oxytocin augmentation and duration of labour with postpartum haemorrhage: A cohort study of nulliparous women |
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| المؤلفون: | Bernitz, Stine, Betran, Ana Pilar, Gunnes, Nina, Zhang, Jun, Blix, Ellen, Øian, Pål, Eggebø, Torbjørn Moe, Dalbye, Rebecka |
| المصدر: | Midwifery ; 123 |
| سنة النشر: | 2023 |
| المجموعة: | Oslo and Akershus University College: ODA (Open Digital Archive) / Høgskolen i Oslo og Akershus (HiOA) |
| الوصف: | Objective: Both duration of labour and use of oxytocin for augmentation are known risk factors for postpartum haemorrhage but distinguishing between the significance of these factors is complex. In this study, we aimed to investigate the association between both labour duration and oxytocin augmentation, for postpartum haemorrhage. Design: A cohort study based on a secondary analysis of a cluster-randomised trial. Participants and setting: Term nulliparous women with a single foetus in cephalic presentation, spon- taneous onset of active labour and a vaginal birth. The participants were originally included in cluster- randomised trial conducted in Norway from December 1, 2014, to January 31, 2017, that aimed to compare the frequency of intrapartum caesarean sections when adhering to the WHO partograph versus Zhang’s guideline. Measurements: The data were analysed through four statistical models. Model 1 investigated the effect of oxytocin augmentation as a dichotomous variable (yes/no); Model 2 investigated the effect of the duration of oxytocin augmentation; Model 3 investigated the effect of the maximum dose of oxytocin; and Model 4 investigated the effect of both the duration of augmentation and the maximum dose of oxytocin. All four models included duration of labour divided into five time-intervals. We used binary logistic regression to estimate the odds ratios of postpartum haemorrhage, defined as blood loss of ≥ 10 0 0 ml, including a random intercept for hospital and mutually adjusting for oxytocin augmentation and labour duration in addition to maternal age, maternal marital status, maternal higher education level, maternal smoking habits in the first trimester, maternal body mass index and birth weight. Findings: Model 1 found a significant association between the use of oxytocin and postpartum haemor- rhage. In Model 2, oxytocin augmentation of ≥ 4.5 h was associated with postpartum haemorrhage. In Model 3, we found an association between a maximum dose of oxytocin of ≥ 20 mU/min and postpar- tum ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0266-6138 |
| العلاقة: | urn:issn:0266-6138; https://hdl.handle.net/11250/3117120Test; https://doi.org/10.1016/j.midw.2023.103705Test; cristin:2153588 |
| DOI: | 10.1016/j.midw.2023.103705 |
| الإتاحة: | https://doi.org/10.1016/j.midw.2023.103705Test https://hdl.handle.net/11250/3117120Test |
| حقوق: | Navngivelse 4.0 Internasjonal ; http://creativecommons.org/licenses/by/4.0/deed.noTest |
| رقم الانضمام: | edsbas.AD2E16BE |
| قاعدة البيانات: | BASE |
| تدمد: | 02666138 |
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| DOI: | 10.1016/j.midw.2023.103705 |