التفاصيل البيبلوغرافية
| العنوان: |
IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia |
| المؤلفون: |
Piccaluga, Pier Paolo, Agostinelli, Claudio, Righi, Simona, Ciccone, Maria, Re, Maria Carla, Musumeci, Giuseppina, Diani, Erica, Signoretto, Caterina, Bon, Isabella, Piccin, Ottavio, Cuneo, Antonio, Tripodo, Claudio, Ponti, Cristina, Zipeto, Donato, Landolfo, Santo, Gibellini, Davide |
| المساهمون: |
Associazione Italiana per la Ricerca sul Cancro |
| المصدر: |
APMIS ; volume 125, issue 6, page 511-522 ; ISSN 0903-4641 1600-0463 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2017 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Chronic lymphocytic leukemia ( CLL ) is the most common leukemia in adults. Its clinical course is typically indolent; however, based on a series of pathobiological, clinical, genetic, and phenotypic parameters, patient survival varies from less than 5 to more than 20 years. In this paper, we show for the first time that the expression of the interferon‐inducible DNA sensor IFI 16, a member of the PYHIN protein family involved in proliferation inhibition and apoptosis regulation, is associated with the clinical outcome in CLL . We studied 99 CLL s cases by immunohistochemistry and 10 CLL s cases by gene expression profiling. We found quite variable degrees of IFI 16 expression among CLL s cases. Noteworthy, we observed that a reduced IFI 16 expression was associated with a very poor survival, but only in cases with ZAP 70/ CD 38 expression. Furthermore, we found that IFI 16 expression was associated with a specific gene expression signature. As IFI 16 can be easily detected by immunohistochemistry or flow cytometry, it may become a part of phenotypic screening in CLL patients if its prognostic role is confirmed in independent series. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/apm.12692 |
| الإتاحة: |
https://doi.org/10.1111/apm.12692Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.ACCFF77E |
| قاعدة البيانات: |
BASE |
