التفاصيل البيبلوغرافية
| العنوان: |
Estimates of drug delivery and comparisons to rifampicin and clofazimine distribution data in experimental granulomas. |
| المؤلفون: |
Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E. Via, James W. Baish, Lei Xu, Veronique Dartois, Clifton E. Barry 3rd, Rakesh K. Jain |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Biotechnology, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, resolved experimental results, rat carcinoma models, explore additional aspects, approximate analytical solutions, interstitial fluid velocity, interstitial fluid pressure, prior experimental results, tb )– compromise, limited oxygen availability, avascular oxygen diffusion, improve molecular transport, div >< p, rabbit tb granulomas, interstitial convection, prior studies, oxygen transport, transcapillary transport, silico <, plasma dilution, physiological abnormalities, necrosis emerge, mouse model, mathematical model |
| الوصف: |
Dimensionless concentration (lines), f , of rifampicin ( A ; RIF) and clofazimine ( B ; CFZ) as a function of dimensionless granuloma radius, ξ , for increasing values of dimensionless granuloma size (the modulus α 0 ) in comparison to experimental data from mouse TB granulomas [ 17 ] (dots). The mean squared error (MSE, see Eq S44) between the theoretical and experimental results for rifampicin and clofazimine are 0.012 and 0.010, respectively (see S2 Table for all raw data, predicted data, and MSE values). |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Estimates_of_drug_delivery_and_comparisons_to_rifampicin_and_clofazimine_distribution_data_in_experimental_granulomas_/25199148Test |
| DOI: |
10.1371/journal.pcbi.1011847.g007 |
| الإتاحة: |
https://doi.org/10.1371/journal.pcbi.1011847.g007Test
https://figshare.com/articles/figure/Estimates_of_drug_delivery_and_comparisons_to_rifampicin_and_clofazimine_distribution_data_in_experimental_granulomas_/25199148Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.ACC571F |
| قاعدة البيانات: |
BASE |
