التفاصيل البيبلوغرافية
| العنوان: |
Study of cellular mechanisms involved in pulmonary hypertension : role of TRP channels in the hyperactivity and the remodelling in rat pulmonary artery ; Etude des mécanismes cellulaires de l'hypertension artérielle pulmonaire : rôle des canaux TRPV dans l'hyperréactivité et le remodelage des artères pulmonaires de rat |
| المؤلفون: |
Dahan, Diana |
| المساهمون: |
Bordeaux 2, Savineau, Jean-Pierre |
| المصدر: |
Theses.fr |
| سنة النشر: |
2011 |
| مصطلحات موضوعية: |
Hypertension pulmonaire, Hypoxie chronique, Monocrotaline, Signalisation calcique, Transient Receptor Potential, Pulmonary hypertension, Chronic hypoxia, Calcium signalling, socio, envir |
| الوصف: |
Pulmonary hypertension (PH)) is the primary pathology of the pulmonary circulation and has a very bad prognostic. This disease is characterized by a hyperreactivity and remodelling of small pulmonary arteries (PA) leading to a progressive increase in pulmonary vascular resistance which ultimately leads to right heart failure and death of the patient. It is admitted that calcium plays an important role both in the mechanisms of remodelling and in the hyperresponsiveness of PA observed in PH. In the present work, we studied the expression and the role of a particular family of calcium channels, TRPV channels, in PA from control rats (normoxic) and pulmonary hypertensive rats (chronically hypoxic and monocrotaline-treated rats). We show that (1) TRPV1, V2 and V4 channels are expressed in the PA and that their expression are increased in PH; (2) stimulation of these channels by specific agonists induces an increase in the intracellular calcium concentration in smooth muscle cells (SMC), (3) the ryanodine receptor type 2 (RRy2) of the sarcoplasmic reticulum is involved in the TRPV4-dependent signaling pathway and its expression is also increased in PH, (4) TRPV1 and TRPV4 channels are involved in the migration of SMC, the fundamental process of remodelling, (5) contractions induced by activation of TRPV2 and TRPV4 in the PA from hypertensive rats are significantly decreased by streptomycine, an inhibitor of stretch activated channels (SAC). This work thus demonstrates the involvement of TRPV channels in both the hyperreactivity and remodelling of PA. New treatments targeting TRPV channels could be an innovative therapeutic approach for pulmonary hypertension. ; L’hypertension pulmonaire (HTP) est la principale pathologie de la circulation pulmonaire et a un très mauvais pronostic. Elle se caractérise par une hyperréactivité et un remodelage des petites artères pulmonaires (AP) entraînant une augmentation progressive des résistances vasculaires pulmonaires, qui, ultimement, aboutit à une insuffisance cardiaque droite ... |
| نوع الوثيقة: |
thesis |
| اللغة: |
French |
| العلاقة: |
10670/1.0yicoj; http://www.theses.fr/2011BOR21843/documentTest |
| الإتاحة: |
http://www.theses.fr/2011BOR21843/documentTest |
| حقوق: |
other |
| رقم الانضمام: |
edsbas.AC9C17E1 |
| قاعدة البيانات: |
BASE |
