التفاصيل البيبلوغرافية
| العنوان: |
Carbazole and Quinazolinone Derivatives from a Fluoride-Tolerant Streptomyces Strain OUCMDZ-5511 |
| المؤلفون: |
Yue Liu, Junsheng Liu, Pengcheng Yan, Konthorn Kachanuban, Peipei Liu, Aiqun Jia, Weiming Zhu |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biochemistry, Pharmacology, Ecology, Sociology, Infectious Diseases, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, supplemented fermentation medium, novel potential inhibitor, fermented solid medium, 2 , 15 , 14 , streptomyces <, h <, violacein production, thailand mangrove, study revealed, spectroscopic analysis, quorum sensing, quinazolinone derivatives, molecular structures, exclusively present, dependent manner, biofilm formation |
| الوصف: |
Six new 9 H -carbazole derivatives ( 1 – 6 ) and nine previously reported compounds ( 7 – 15 ) were isolated from a fermented solid medium of the Thailand mangrove-derived Streptomyces strain, OUCMDZ-5511, under fluoride stress. Compounds 2 – 5 , 12 , and 15 were exclusively present in the fluoride-supplemented fermentation medium, while compounds 7 – 9 , 13 , and 14 were newly discovered natural products. The molecular structures of the compounds were identified by a spectroscopic analysis. The new compound 2 displayed antiquorum sensing activity against Chromobacterium violaceum ATCC 12472 by reducing the violacein production and inhibiting the biofilm formation in a concentration-dependent manner. The study revealed that compound 2 could be a novel potential inhibitor of quorum sensing. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Carbazole_and_Quinazolinone_Derivatives_from_a_Fluoride-Tolerant_i_Streptomyces_i_Strain_OUCMDZ-5511/25395393Test |
| DOI: |
10.1021/acs.jafc.4c00780.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.jafc.4c00780.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.AC9A0A38 |
| قاعدة البيانات: |
BASE |
