دورية أكاديمية
Basal and one-month differed neutrophil, lymphocyte and platelet values and their ratios strongly predict the efficacy of checkpoint inhibitors immunotherapy in patients with advanced BRAF wild-type melanoma
| العنوان: | Basal and one-month differed neutrophil, lymphocyte and platelet values and their ratios strongly predict the efficacy of checkpoint inhibitors immunotherapy in patients with advanced BRAF wild-type melanoma |
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| المؤلفون: | Guida M., Bartolomeo N., Quaresmini D., Quaglino P., Madonna G., Pigozzo J., Di Giacomo A. M., Minisini A. M., Tucci M., Spagnolo F., Occelli M., Ridolfi L., Queirolo P., De Risi I., Valente M., Sciacovelli A. M., Chiarion Sileni V., Ascierto P. A., Stigliano L., Strippoli S. |
| المساهمون: | Guida, M., Bartolomeo, N., Quaresmini, D., Quaglino, P., Madonna, G., Pigozzo, J., Di Giacomo, A. M., Minisini, A. M., Tucci, M., Spagnolo, F., Occelli, M., Ridolfi, L., Queirolo, P., De Risi, I., Valente, M., Sciacovelli, A. M., Chiarion Sileni, V., Ascierto, P. A., Stigliano, L., Strippoli, S. |
| سنة النشر: | 2022 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | Checkpoint inhibitor, Metastatic melanoma, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Blood Platelet, Human, Immunotherapy, Lymphocyte, Prognosi, Prospective Studie, Proto-Oncogene Proteins B-raf, Retrospective Studie, Melanoma, Neutrophils |
| الوصف: | Background To evaluate the capability of basal and one-month differed white blood cells (WBC), neutrophil, lymphocyte and platelet values and their ratios (neutrophils-to-lymphocytes ratio, NLR, and platelets-to-lymphocytes ratio, PLR) in predicting the response to immune checkpoint inhibitors (ICI) in metastatic melanoma (MM). Methods We performed a retrospective study of 272 BRAF wild-type MM patients treated with first line ICI. Bivariable analysis was used to correlate patient/tumor characteristics with clinical outcomes. Variations between time 1 and time 0 (Delta) of blood parameters were also calculated and dichotomized using cut-off values assessed by ROC curve. Results At baseline, higher neutrophils and NLR negatively correlated with PFS, OS and disease control rate (DCR). Higher PLR was also associated with worse OS. In multivariable analysis, neutrophils (p = 0.003), WBC (p = 0.069) and LDH (p = 0.07) maintained their impact on PFS, while OS was affected by LDH (p < 0.001), neutrophils (p < 0.001) and PLR (p = 0.022), while DCR by LDH (p = 0.03) and neutrophils (p = 0.004). In the longitudinal analysis, PFS negatively correlated with higher Delta platelets (p = 0.039), Delta WBC (p < 0.001), and Delta neutrophils (p = 0.020), and with lower Delta lymphocytes (p < 0.001). Moreover, higher Delta NLR and Delta PLR identified patients with worse PFS, OS and DCR. In the multivariable model, only Delta NLR influenced PFS (p = 0.004), while OS resulted affected by higher Delta WBC (p < 0.001) and lower Delta lymphocytes (p = 0.038). Higher Delta WBC also affected the DCR (p = 0.003). When clustering patients in 4 categories using basal LDH and Delta NLR, normal LDH/lower Delta NLR showed a higher PFS than high LDH/higher Delta NLR (20 vs 5 months). Moreover, normal LDH/higher Delta lymphocytes had a higher OS than high LDH/lower Delta lymphocytes (50 vs. 10 months). Conclusions Baseline and early variations of blood cells, together with basal LDH, strongly predict the efficacy of ICI in MM. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35382857; info:eu-repo/semantics/altIdentifier/wos/WOS:000778499200004; volume:20; issue:1; firstpage:1; lastpage:15; numberofpages:15; journal:JOURNAL OF TRANSLATIONAL MEDICINE; https://hdl.handle.net/11365/1221041Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85127719534; https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03359-xTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981693Test/ |
| DOI: | 10.1186/s12967-022-03359-x |
| الإتاحة: | https://doi.org/10.1186/s12967-022-03359-xTest https://hdl.handle.net/11365/1221041Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8981693Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AC79185 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12967-022-03359-x |
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