دورية أكاديمية
A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance
| العنوان: | A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance |
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| المؤلفون: | Mudhar, Hardeep Singh, Krishna, Yamini, Cross, Simon, Auw-Haedrich, Claudia, Barnhill, Raymond, Cherepanoff, Svetlana, Eagle, Ralph, Farmer, James, Folberg, Robert, Grossniklaus, Hans, Herwig-Carl, Martina C., Hyrcza, Martin, Lassalle, Sandra, Loeffler, Karin U., Moulin, Alexandre, Milman, Tatyana, Verdijk, Robert M., Heegaard, Steffen, Coupland, Sarah E. |
| المصدر: | Wills Eye Hospital Papers |
| بيانات النشر: | Jefferson Digital Commons |
| سنة النشر: | 2023 |
| المجموعة: | Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) |
| مصطلحات موضوعية: | conjunctival melanoma, Humans, Melanoma, Prognosis, Reproducibility of Results, Eosine Yellowish-(YS), Hematoxylin, Melanocytes, Skin Neoplasms, Melanosis, World Health Organization, Multicenter Studies as Topic, Medicine and Health Sciences, Oncology, Ophthalmology |
| الوصف: | Several nomenclature and grading systems have been proposed for conjunctival melanocytic intraepithelial lesions (C-MIL). The fourth "WHO Classification of Eye Tumors" (WHO-EYE04) proposed a C-MIL classification, capturing the progression of noninvasive neoplastic melanocytes from low- to high-grade lesions, onto melanoma in situ (MIS), and then to invasive melanoma. This proposal was revised to the WHO-EYE05 C-MIL system, which simplified the high-grade C-MIL, whereby MIS was subsumed into high-grade C-MIL. Our aim was to validate the WHO-EYE05 C-MIL system using digitized images of C-MIL, stained with hematoxylin and eosin and immunohistochemistry. However, C-MIL cases were retrieved from 3 supraregional ocular pathology centers. Adequate conjunctival biopsies were stained with hematoxylin and eosin, Melan-A, SOX10, and PReferentially expressed Antigen in Melanoma. Digitized slides were uploaded on the SmartZoom platform and independently scored by 4 ocular pathologists to obtain a consensus score, before circulating to 14 expert eye pathologists for independent scoring. In total, 105 cases from 97 patients were evaluated. The initial consensus diagnoses using the WHO-EYE04 C-MIL system were as follows: 28 benign conjunctival melanoses, 13 low-grade C-MIL, 37 high-grade C-MIL, and 27 conjunctival MIS. Using this system resulted in 93% of the pathologists showing only fair-to-moderate agreement (kappa statistic) with the consensus score. The WHO-EYE05 C-MIL system (with high-grade C-MIL and MIS combined) improved consistency between pathologists, with the greatest level of agreement being seen with benign melanosis (74.5%) and high-grade C-MIL (85.4%). Lowest agreements remained between pathologists for low-grade C-MIL (38.7%). Regarding WHO-EYE05 C-MIL scoring and clinical outcomes, local recurrences of noninvasive lesions developed in 8% and 34% of the low- and high-grade cases. Invasive melanoma only occurred in 47% of the cases that were assessed as high-grade C-MIL. This extensive international ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://jdc.jefferson.edu/willsfp/209Test; https://jdc.jefferson.edu/context/willsfp/article/1209/viewcontent/RED_ID_5992.pdfTest; https://jdc.jefferson.edu/context/willsfp/article/1209/filename/0/type/additional/viewcontent/mmc1.pptxTest; https://jdc.jefferson.edu/context/willsfp/article/1209/filename/1/type/additional/viewcontent/mmc2.docxTest |
| الإتاحة: | https://jdc.jefferson.edu/willsfp/209Test https://jdc.jefferson.edu/context/willsfp/article/1209/viewcontent/RED_ID_5992.pdfTest https://jdc.jefferson.edu/context/willsfp/article/1209/filename/0/type/additional/viewcontent/mmc1.pptxTest https://jdc.jefferson.edu/context/willsfp/article/1209/filename/1/type/additional/viewcontent/mmc2.docxTest |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.AC209317 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |