دورية أكاديمية
Isolated hyperglycaemia does not increase VLDL-triacylglycerol secretion in type 1 diabetic men
| العنوان: | Isolated hyperglycaemia does not increase VLDL-triacylglycerol secretion in type 1 diabetic men |
|---|---|
| المؤلفون: | Johansen, Rakel Fuglsang, Søndergaard, Esben, Sørensen, Lars Peter, Sørensen, Birgitte, Christiansen, Jens Sandahl, Nielsen, Søren |
| المصدر: | Johansen , R F , Søndergaard , E , Sørensen , L P , Sørensen , B , Christiansen , J S & Nielsen , S 2015 , ' Isolated hyperglycaemia does not increase VLDL-triacylglycerol secretion in type 1 diabetic men ' , Diabetologia , vol. 58 , no. 2 , pp. 355-62 . https://doi.org/10.1007/s00125-014-3422-6Test |
| سنة النشر: | 2015 |
| المجموعة: | Aarhus University: Research |
| الوصف: | AIMS/HYPOTHESIS: In type 1 diabetes, abnormalities of both glucose and lipoprotein metabolism are seen. The relationship between these factors is not understood, but studies indicate that hyperglycaemia may increase hepatic VLDL-triacylglycerol (VLDL-TG) secretion and reduce VLDL-TG fatty acid oxidation, which could lead to the development of dyslipidaemia. The aim of this study was to determine the isolated effect of hyperglycaemia on VLDL-TG and NEFA kinetics in men with type 1 diabetes. METHODS: VLDL-TG and palmitate kinetics were measured in eight men with type 1 diabetes using ex vivo labelled VLDL-TG and palmitate tracers. A 2.5 h basal period (plasma glucose 5 mmol/l) was followed by a 4 h hyperglycaemic period (plasma glucose 16 mmol/l). Steady-state VLDL-TG kinetics (VLDL-TG secretion, clearance and oxidation rates) were assessed by an isotope dilution technique using an intravenous primed-constant infusion of ex vivo labelled [1-(14)C]VLDL-TG in combination with sampling of blood and expired air. Palmitate turnover was measured using [9,10-(3)H]palmitate. RESULTS: The VLDL-TG secretion rate (36.0 ± 9.6 vs 30.8 ± 6.1 μmol/min, NS) and clearance rate (209 ± 30.4 vs 197 ± 41.7 ml/min, NS) were unchanged during the basal and hyperglycaemic periods, resulting in unchanged VLDL-TG concentrations (0.25 ± 0.11 μmol/l vs 0.28 ± 0.10 μmol/l, NS). In addition, VLDL-TG fatty acid oxidation and palmitate flux were not changed during hyperglycaemia. CONCLUSIONS/INTERPRETATION: Four hours of acute hyperglycaemia (16 mmol/l) without a concomitant increase in insulin does not alter VLDL-TG and NEFA kinetics in men with type 1 diabetes. Clinical trial registry number: NCT01178957. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s00125-014-3422-6 |
| الإتاحة: | https://doi.org/10.1007/s00125-014-3422-6Test https://pure.au.dk/portal/da/publications/isolated-hyperglycaemia-does-not-increase-vldltriacylglycerol-secretion-in-type-1-diabetic-menTest(3f74321f-a956-4aee-afbf-e464cdabb07a).html |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AC0B47C5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00125-014-3422-6 |
|---|