التفاصيل البيبلوغرافية
| العنوان: |
Microfluidic Quantification of Blood Vessel Interactions in an Engineered Tumor Microenvironment |
| المؤلفون: |
Waller, Jacob |
| المساهمون: |
Song, Jonathan |
| بيانات النشر: |
The Ohio State University |
| سنة النشر: |
2020 |
| المجموعة: |
Ohio State University (OSU): Knowledge Bank |
| مصطلحات موضوعية: |
Placental Growth Factor (PlGF), Angiogensis, Tumor Microenvironment, Microfluidics |
| الوصف: |
The environment around a tumor is known as the tumor microenvironment and consists of blood and lymphatic vessels, tissue components known as the extracellular matrix (ECM), signaling molecules, and other supporting cells. The unique biochemical and biomechanical properties of the tumor microenvironment have emerged as important contributors to cancer growth and spread. Recent studies suggest that placental growth factor (PlGF), a member of the VEGF family, has elevated levels in cancer patients when treated with VEGF inhibitors. Human Umbilical Vein Endothelial Cells (HUVECs) were seeded in the outer channels of a 3-channel microfluidic blood vessel analogue model against a collagen matrix in the center channel. This device was used to investigate how PlGF promotes blood vessel growth (also known as angiogenesis). HUVECs were treated with PlGF-1 and PlGF-2, and their sprouting area was compared. PlGF-1 showed improved sprouting area over the control for the duration of the three-day culture. PlGF2 showed statistically significant improvement in sprouting area over the control for the duration of the three-day culture. This result suggests the proangiogenic potential of both isoforms of PlGF. Showing the proangiogenic potential of PlGF provides another avenue for targeted antiangiogenic cancer therapies. ; Undergraduate Honors Committee ; A three-year embargo was granted for this item. ; Academic Major: Biomedical Engineering |
| نوع الوثيقة: |
thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
The Ohio State University. Department of Biomedical Engineering Honors Theses; 2020; https://kb.osu.edu/handle/1811/103700Test |
| الإتاحة: |
https://kb.osu.edu/handle/1811/103700Test |
| رقم الانضمام: |
edsbas.ABD4CF9D |
| قاعدة البيانات: |
BASE |
