دورية أكاديمية
In vitro and in vivo effects of the urokinase plasminogen activator inhibitor WX-340 on anaplastic thyroid cancer cell lines
| العنوان: | In vitro and in vivo effects of the urokinase plasminogen activator inhibitor WX-340 on anaplastic thyroid cancer cell lines |
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| المؤلفون: | Baldini E., Presutti D., Favoriti P., Santini S., Papoff G., Tuccilli C., Carletti R., Di Gioia C., Lori E., Ferent I. C., Gagliardi F., Catania A., Pironi D., Tripodi D., D'andrea V., Sorrenti S., Ruberti G., Ulisse S. |
| المساهمون: | Baldini, E., Presutti, D., Favoriti, P., Santini, S., Papoff, G., Tuccilli, C., Carletti, R., Di Gioia, C., Lori, E., Ferent, I. C., Gagliardi, F., Catania, A., Pironi, D., Tripodi, D., D'Andrea, V., Sorrenti, S., Ruberti, G., Ulisse, S. |
| بيانات النشر: | MDPI AG Basel, Switzerland |
| سنة النشر: | 2022 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | anaplastic thyroid cancer, BHT-101, CAL-62, cell adhesion, cell migration, proliferation, urokinase plasminogen activator, WX-340, xenograft, cell line, human, neoplasm invasivene, peptides, cyclic, plasminogen activator inhibitor 1, plasminogen activator inhibitor 2, urokinase-type plasminogen activator, thyroid carcinoma, anaplastic, thyroid neoplasms |
| الوصف: | Increased expression of the urokinase-type plasminogen activator (uPA) system is associated with tumor invasion, neo-angiogenesis, and metastatic spread, and has been shown to positively correlate with a poor prognosis in several cancer types, including thyroid carcinomas. In recent years, several uPA inhibitors were found to have anticancer effects in preclinical studies and in some phase II clinical trials, which prompted us to evaluate uPA as a potential therapeutic target for the treatment of patients affected by the most aggressive form of thyroid cancer, the anaplastic thyroid carcinoma (ATC). In this study, we evaluated the in vitro and in vivo effects of WX-340, a highly specific and selective uPA inhibitor, on two ATC-derived cell lines, CAL-62 and BHT-101. The results obtained indicated that WX-340 was able to reduce cell adhesion and invasiveness in a dose-dependent manner in both cell lines. In addition, WX-340 increased uPA receptor (uPAR) protein levels without affecting its plasma membrane concentration. However, this compound was unable to significantly reduce ATC growth in a xenograft model, indicating that uPA inhibition alone may not have the expected therapeutic effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35409084; info:eu-repo/semantics/altIdentifier/wos/WOS:000782025800001; volume:23; issue:7; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11573/1629481Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85127124919 |
| DOI: | 10.3390/ijms23073724 |
| الإتاحة: | https://doi.org/10.3390/ijms23073724Test http://hdl.handle.net/11573/1629481Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.ABCA2E95 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms23073724 |
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