دورية أكاديمية
Comparison of refugee patients with cystic fibrosis and their counterpart children from Turkey during the war
| العنوان: | Comparison of refugee patients with cystic fibrosis and their counterpart children from Turkey during the war |
|---|---|
| المؤلفون: | Yılmaz A.İ., Pekcan S., Eyüboğlu T.Ş., Hangül M., Arslan H., Kılınç A.A., Çokuğraş H. |
| بيانات النشر: | Springer Science and Business Media Deutschland GmbH |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Children, Cystic fibrosis, Refugee, War |
| الوصف: | Since the outbreak of the Syrian civil war in 2011, the population of Arab refugees in Turkey has rapidly increased. While cystic fibrosis (CF) is believed to be rare among Arabs, recent studies suggest it is underdiagnosed. This study aims to present the demographic, clinical, and genetic characteristics of CF patients among Arab refugees in Turkey. Additionally, a comparison is made between the findings in the National CF Registry 2021 in Turkey (NCFRT) and the refugee CF patient group. The study included refugee patients between the ages of 0 and 18 years who were diagnosed with CF and received ongoing care at pediatric pulmonology centers from March 2011 to March 2021. The study examined demographic information, age at diagnosis, age of diagnosis of patients through CF newborn screening (NBS), presenting symptoms, CF transmembrane conductance regulator (CFTR) mutation test results, sputum culture results, weight, height, and body mass index (BMI) z score. Their results were compared with the NCFRT results. The study included 14 pediatric pulmonology centers and 87 patients, consisting of 46 (52.9%) boys and 41 (47.1%) girls. All of the patients were Arab refugees, with 80 (92%) being Syrian. All the patients were diagnosed in Turkey. The median age at diagnosis of patients was 22.33 (interquartile range, 1–258) months. The median age of diagnosis of patients through NBS was 4.2 (interquartile range, 1–12) months. The median age of older patients, who were unable to be included in the NBS program, was 32.3 (interquartile range, 3–258) months. Parental consanguinity was observed in 52 (59.7%) patients. The mutation that was most frequently found was F508del, which accounted for 22.2% of the cases. It was present in 20 patients, constituting 32 out of the total 144 alleles. There was a large number of genetic variations. CFTR genotyping could not be conducted for 12 patients. These patients had high sweat tests, and their genetic mutations could not be determined due to a lack of data. Compared to NCFRT, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 03406199 |
| العلاقة: | European Journal of Pediatrics; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1007/s00431-024-05431-8Test; https://hdl.handle.net/20.500.12831/19453Test; 2-s2.0-85182991146 |
| DOI: | 10.1007/s00431-024-05431-8 |
| الإتاحة: | https://doi.org/10.1007/s00431-024-05431-8Test https://doi.org/20.500.12831/19453Test https://hdl.handle.net/20.500.12831/19453Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AB846EBF |
| قاعدة البيانات: | BASE |
| تدمد: | 03406199 |
|---|---|
| DOI: | 10.1007/s00431-024-05431-8 |