دورية أكاديمية
Metabolic risk factors in young adults infected with HIV since childhood compared with the general population ; PLoS One
| العنوان: | Metabolic risk factors in young adults infected with HIV since childhood compared with the general population ; PLoS One |
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| المؤلفون: | ARRIVE, Elise, VIARD, J. P., SALANAVE, B., DOLLFUS, C., MATHERON, S., RELIQUET, V., AREZES, E., NAILLER, L., VIGOUROUX, C., WARSZAWSKI, J. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | IDLIC, Sciences du Vivant [q-bio]/Santé publique et épidémiologie |
| الوصف: | AIM: Metabolic risk factors are poorly documented for the first generation of young adults who have lived with HIV since childhood. We compared their metabolic profile with that of adults of same age from the general population. METHODS: We conducted a cross-sectional analysis of data from two populations: (1) COVERTE (ANRS-CO19), a French national cohort of 18 to 30-year-old patients HIV-infected since childhood, and (2) ENNS, a national cross-sectional population-based household survey on nutrition. Body mass index (BMI), blood pressure, waist circumference, fasting glucose, triglycerides, and HDL-, LDL- and total cholesterol were measured in both studies. Direct standardization on overweight and education level and logistic regression were used to compare the prevalence of metabolic abnormalities between the two populations. RESULTS: Data from 268 patients from COVERTE and 245 subjects from ENNS were analyzed. Tobacco use was similar in both groups. HIV-infected patients had increased mean waist-to-hip ratio and triglycerides to HDL-cholesterol ratio and decreased mean HDL-cholesterol as compared to their counterparts from the general population in both genders. In HIV-infected patients, metabolic syndrome was identified in 13.2% of men (95% confidence interval [CI]: 7.1-19.2) and 10.4% (95% CI: 5.4-15.3) of women versus 10.6% (95%CI: 1.5-19.7) and 1.7% (95%CI: 0-4.1) in subjects from the general population, respectively. CONCLUSION: Young adults infected with HIV since childhood had a higher prevalence of dyslipidemia and metabolically detrimental fat distribution than adults of same age of the general population, supporting close monitoring for cardiometabolic diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | 1932-6203 (Electronic) 1932-6203 (Linking); https://oskar-bordeaux.fr/handle/20.500.12278/11385Test |
| DOI: | 10.1371/journal.pone.0206745 |
| الإتاحة: | https://doi.org/20.500.12278/11385Test https://doi.org/10.1371/journal.pone.0206745Test https://oskar-bordeaux.fr/handle/20.500.12278/11385Test https://hdl.handle.net/20.500.12278/11385Test |
| حقوق: | Attribution 3.0 United States ; open ; http://creativecommons.org/licenses/by/3.0/usTest/ |
| رقم الانضمام: | edsbas.AAB1706E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0206745 |
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