دورية أكاديمية
Conjunction of tumor cells with lymphocytes: Implications for tumor invasion and metastasis
| العنوان: | Conjunction of tumor cells with lymphocytes: Implications for tumor invasion and metastasis |
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| المؤلفون: | Song, Guohong, Ren, Jun, Stojadinovic, Alexander, Chen, Wen, Sahab, Ziad, Fu, Sidney W., Man, Yan-gao |
| المساهمون: | Man, YG (reprint author), Henry Jackson Fdn, Diagnost & Translat Res Ctr, 401 Profess Dr, Gaithersburg, MD 20879 USA., Henry Jackson Fdn, Diagnost & Translat Res Ctr, Gaithersburg, MD 20879 USA., Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Canc Hosp & Inst, Beijing 100142, Peoples R China., Walter Reed Natl Med Ctr, Bethesda, MD 20889 USA., Uniformed Serv Univ Hlth Sci, Bethesda, MD 20889 USA., US Mil Canc Inst, Bethesda, MD 20889 USA., Washington DC VA Med Ctr, Dept Pathol, Washington, DC 20422 USA., Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA., George Washington Univ, Med Ctr, Dept Med, Div Genom Med, Washington, DC 20037 USA., George Washington Univ, Med Ctr, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA., Henry Jackson Fdn, Diagnost & Translat Res Ctr, 401 Profess Dr, Gaithersburg, MD 20879 USA. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | cancer epidemiology |
| سنة النشر: | 2012 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Breast cancer, Metastasis, Tumor cell capsule, Myoepithelial cell layer, Cell degeneration, RESULTANT AUTO-IMMUNOREACTIONS, REGULATORY T-CELLS, BREAST-CANCER, PROSTATE-CANCER, FOCAL DEGENERATION, PROGRESSION, EXPRESSION, MACROPHAGES, MICRORNAS, FUSION |
| الوصف: | Our previous studies have led to a novel hypothesis that tumor metastasis is triggered by aberrant lymphocyte infiltration that disrupts intercellular junctions and surface adhesion molecules and causes dissociation of tumor cells from the primary tumor core, allowing lymphocytes to conjoin with dissociated tumor cells and physically 'drag' them to different tissue sites. Our hypothesis is supported by morphological and immunohistochemical data from multiple types of human cancer. This hypothesis challenges the traditional belief that the physical conjunction between tumor cells and lymphocytes would lead to degeneration of the tumor cells. To validate our hypothesis, H&E and immunostained sections were examined under high magnification to identify potential signs of degeneration-related changes. Our study revealed that >60% of isolated tumor cells overlying focal capsule disruptions, or within the stroma and vascular structures, were physically conjoined with lymphocytes to form tumor cell-lymphocyte chimeras (TLCs). Approximately 90% of the tumor cell partners of TLCs were morphologically indistinguishable from their counterparts within the tumor core. In addition, one third of the tumor cells of TLCs expressed high levels of cell proliferation specific proteins, or were undergoing mitosis. Our study also revealed that a subset of dilated lymphatic ducts or blood vessels at the site of focal capsule disruptions harbored variable numbers of tumor cells, and the wall of these structures was in direct physical continuity with the myoepithelial cell layer. Our study suggests that the onset of tumor metastasis may occur in two forms: (1) lymphocyte-mediated shuttling that allows lymphocytes to physically 'drag' tumor cells to different sites, and (2) tumor progenitor-mediated angiogenesis that allows tumor cells to directly enter the vascular structures. (C) 2011 Elsevier Ltd. All rights reserved. ; Oncology ; Public, Environmental & Occupational Health ; SCI(E) ; PubMed ; 3 ; ARTICLE ; 4 ; 354-363 ; 36 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1877-7821 |
| العلاقة: | CANCER EPIDEMIOLOGY.2012,36,(4),354-363.; 659557; http://hdl.handle.net/20.500.11897/191791Test; WOS:000307216700015 |
| DOI: | 10.1016/j.canep.2011.12.006 |
| الإتاحة: | https://doi.org/20.500.11897/191791Test https://doi.org/10.1016/j.canep.2011.12.006Test https://hdl.handle.net/20.500.11897/191791Test |
| رقم الانضمام: | edsbas.AA9A4916 |
| قاعدة البيانات: | BASE |
| تدمد: | 18777821 |
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| DOI: | 10.1016/j.canep.2011.12.006 |