دورية أكاديمية
The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours.
| العنوان: | The proliferation marker Chromatin Assembly Factor-1 is of clinical value in predicting the biological behaviour of salivary gland tumours. |
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| المؤلفون: | STAIBANO, STEFANIA, MASCOLO, MASSIMO, ROCCO, ALBA, ILARDI, GENNARO, SIANO, MARIA, CALIFANO, LUIGI, DE ROSA, GAETANO, Lo Muzio L, Pannone G, Vecchione ML, Nugnes L, Zamparese R, Bufo P |
| المساهمون: | Staibano, Stefania, Mascolo, Massimo, Rocco, Alba, Lo Muzio, L, Ilardi, Gennaro, Siano, Maria, Pannone, G, Vecchione, Ml, Nugnes, L, Califano, Luigi, Zamparese, R, Bufo, P, DE ROSA, Gaetano |
| سنة النشر: | 2011 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Cell Proliferation, Child, Chromatin Assembly Factor-1, biosynthesis, Female, Humans, Immunohistochemistry, Male, Middle Aged, Prognosis, Proportional Hazards Models, ROC Curve, Salivary Gland Neoplasm, metabolism/mortality/pathology, Sensitivity and Specificity, Tumor Marker, Biological, analysis |
| الوصف: | Salivary gland tumours (SGT) constitute a diagnostically challenging group of neoplasms with frequently unpredictable clinical outcome. The proliferation rate facilitates the identification of aggressive SGT. The Chromatin Assembly Factor-1 (CAF-1) is a major epigenetic regulator of nuclear chromatin organization during DNA replication. It plays a critical function in human tumourigenesis and has been proposed as a new proliferation and prognostic marker for some malignancies. This study focused on the role of CAF-1/p60 protein as a marker of clinical value for SGT. The expression of CAF-1/p60 was evaluated by immunohistochemistry on a retrospective series of 362 surgically excised benign and malignant SGT with different histogenesis and, when available, on fine-needle pre-surgical cytological biopsies. The resulting data were compared with traditional prognostic parameters, including the expression of the routine proliferation marker ki67/MIB1. CAF-1/p60 was detectable in all SGT, with highest degree of expression in metastasizing malignant tumours. Moreover, the cases of benign tumours which progressed to carcinoma during the follow-up, showed significantly higher CAF-1/p60 expression than non-progressing benign SGT, both on histological sections and cytological smears of the primary tumour. Cox's multiple regression analysis selected CAF-1/p60 expression as the best independent predictor of cancer development for benign SGT (p<0.0001), and the best independent predictor of metastasis onset for malignant tumours (p<0.0004). Overexpression of CAF-1/p60, on histological and/or cytological samples, characterizes malignant SGT with aggressive behaviour, irrespective of their specific histotype, and allows the early diagnosis of progression toward malignancy of morphologically benign tumours. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000286303800002; volume:25; firstpage:13; lastpage:22; numberofpages:9; journal:ONCOLOGY REPORTS; http://hdl.handle.net/11588/458379Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-78650731401 |
| DOI: | 10.3892/or_00001036 |
| الإتاحة: | https://doi.org/10.3892/or_00001036Test http://hdl.handle.net/11588/458379Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AA961B23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3892/or_00001036 |
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