دورية أكاديمية
Metabolic phenotypes of excess body weight and risk of impaired kidney function
| العنوان: | Metabolic phenotypes of excess body weight and risk of impaired kidney function |
|---|---|
| المؤلفون: | A. Leone, F. Menichetti, R. De Amicis, A. Foppiani, S. Bertoli, A. Battezzati |
| المساهمون: | A. Leone, F. Menichetti, R. De Amici, A. Foppiani, S. Bertoli, A. Battezzati |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Settore MED/49 - Scienze Tecniche Dietetiche Applicate, Settore BIO/09 - Fisiologia |
| الوصف: | Introduction: Excess body weight and metabolic syndrome are major public health problems worldwide that frequently coexist, and are both risk factors for reduced kidney function (RKF). However, some people with excess body weight do not present metabolic abnormalities and are considered metabolically healthy (MHEW). Several studies reported that people with excess body weight had a higher risk for RKF, independently from the metabolic phenotype, than healthy people with normal weight. However, it is unknown if MHEW have a different risk of impaired kidney function from metabolically unhealthy people with excess body weight (MUEW). Methods: A cross-sectional study of 8263 participants (67.5% females, mean age: 47±13 years) with overweight (52.9%) and obesity (47.1%) recruited at the International Center for the Assessment of Nutritional Status (ICANS, University of Milan) was carried out. Anthropometric measurements (weight, height, and waist circumference (WC)), blood pressure, blood parameters (glucose, triglycerides, HDL-cholesterol, and creatinine) were taken. Lifestyle-related information (physical activity and smoking habits) were investigated. MHEW were defined as people with overweight or obesity but free of metabolic abnormalities defined according harmonized criteria for metabolic syndrome (with exclusion of WC). MUEW were defined as people with overweight or obesity and at least one metabolic syndrome criteria (with exclusion of WC). Glomerular filtration rate (eGFR) was calculated through the EPI-CKD predictive formula. Normal renal function was defined as eGFR 90-125 ml/min/1.73m2. Higher values indicated hyperfiltration, values ranged 60-89 ml/min/1.73m2 a mild RKF, while values <60 ml/min/1.73m2 indicated a moderate/severe RKF. A multinomial logistic model adjusted for sex, age, BMI, smoking and physical activity was used to assess the impact of the metabolic phenotypes on the risk of hyperfiltration, mild RKF and moderate/severe RKF, which lead to odd ratio (OR) as measure of association. In ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37231832; European Congress on Obesity; volume:16; issue:Suppl 1; firstpage:135; lastpage:135; numberofpages:1; journal:OBESITY FACTS; https://hdl.handle.net/2434/973628Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85160455346; https://karger.com/ofa/article/16/SupplTest. 1/1/843563/30th-European-Congress-on-Obesity-ECO-2023 |
| الإتاحة: | https://hdl.handle.net/2434/973628Test https://karger.com/ofa/article/16/SupplTest. 1/1/843563/30th-European-Congress-on-Obesity-ECO-2023 |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AA481148 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |