دورية أكاديمية
Intrarenal Vascular Resistance is Associated with a Prothrombotic State in Hypertensive Patients
| العنوان: | Intrarenal Vascular Resistance is Associated with a Prothrombotic State in Hypertensive Patients |
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| المؤلفون: | Catena, Cristiana, Colussi, Gian Luca, Novello, Marileda, Fagotto, Valentina, Sechi, Leonardo Alberto |
| المساهمون: | Catena, Cristiana, Colussi, Gian Luca, Novello, Marileda, Fagotto, Valentina, Sechi, Leonardo Alberto |
| سنة النشر: | 2016 |
| المجموعة: | Università degli Studi di Udine: CINECA IRIS |
| مصطلحات موضوعية: | D-dimer, Fibrinogen, Hypertensive nephroangiosclerosi, Prothrombotic state, Renal ultrasound, Adult, Age Factor, Aged, Female, Fibrin Fibrinogen Degradation Product, Human, Hypertension, Kidney, Kidney Disease, Male, Middle Aged, Vascular Resistance, Thrombophilia, Nephrology, Cardiology and Cardiovascular Medicine |
| الوصف: | Background/Aims: Hypertensive nephroangiosclerosis is associated with progressive increase of intrarenal vascular resistance. In addition to blood pressure, other factors can contribute to hypertensive renal damage including a prothrombotic state. We investigated the relationship between hemostatic markers and intrarenal vascular resistance in hypertension. Methods: In 115 untreated, nondiabetic, hypertensive subjects free of cardiovascular complications and advanced renal function impairment, we measured 24-hour creatinine clearance (GFR) and urinary albumin excretion (UAE), fasting plasma glucose, HOMA-index, and plasma levels of fibrinogen, D-dimer, prothrombin fragment 1+2, plasminogen activator inhibitor-1, homocysteine, and lipoprotein(a). In all patients, measurement of intrarenal resistance was obtained by renal Doppler ultrasound with calculation of the renal resistance index (RI). Results: Patients in the highest tertile of RI were older and had greater body mass index, pulse pressure, fibrinogen, and D-dimer levels and lower GFR than patients in the lowest RI tertile. RI was directly correlated with age, pulse pressure, HOMA-index, UAE, D-dimer, and inversely with GFR. On multivariate analysis, RRI was independently associated with age, GFR, and plasma D-dimer. Conclusions: A prothrombotic state is associated with increased intrarenal vascular resistance in nondiabetic hypertensive patients and might contribute to the early stages of hypertensive renal disease. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000392937800019; volume:41; issue:6; firstpage:929; lastpage:936; numberofpages:8; journal:KIDNEY & BLOOD PRESSURE RESEARCH; http://hdl.handle.net/11390/1120891Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85001129882; www.karger.com/journals/kbr/kbr_jh.htm |
| DOI: | 10.1159/000452594 |
| الإتاحة: | https://doi.org/10.1159/000452594Test http://hdl.handle.net/11390/1120891Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AA328B8A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000452594 |
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