دورية أكاديمية
A prospective study validating a clinical scoring system and demonstrating phenotypical-genotypical correlations in Silver-Russell syndrome
| العنوان: | A prospective study validating a clinical scoring system and demonstrating phenotypical-genotypical correlations in Silver-Russell syndrome |
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| المؤلفون: | Azzi, Salah, Salem, Jennifer, Thibaud, Nathalie, Chantot-Bastaraud, Sandra, Lieber, Eli, Netchine, Irène, Harbison, Madeleine D. |
| المساهمون: | Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Epigenetics Programme, The Babraham Institute Cambridge, UK, MAGIC Foundation, Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (UCLA), University of California (UC)-University of California (UC), Department of Pediatrics New York, Icahn School of Medicine at Mount Sinai New York (MSSM) |
| المصدر: | ISSN: 0022-2593. |
| بيانات النشر: | HAL CCSD BMJ Publishing Group |
| سنة النشر: | 2015 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | [SDV.GEN]Life Sciences [q-bio]/Genetics |
| الوصف: | International audience ; Background Multiple clinical scoring systems have been proposed for Silver-Russell syndrome (SRS). Here we aimed to test a clinical scoring system for SRS and to analyse the correlation between (epi)genotype and phenotype. Subjects and methods Sixty-nine patients were examined by two physicians. Clinical scores were generated for all patients, with a new, six-item scoring system: (1) small for gestational age, birth length and/or weight ≤−2SDS, (2) postnatal growth retardation (height ≤−2SDS), (3) relative macrocephaly at birth, (4) body asymmetry, (5) feeding difficulties and/or body mass index (BMI) ≤−2SDS in toddlers; (6) protruding forehead at the age of 1–3 years. Subjects were considered to have likely SRS if they met at least four of these six criteria. Molecular investigations were performed blind to the clinical data. Results The 69 patients were classified into two groups (Likely-SRS (n=60), Unlikely-SRS (n=9)). Forty-six Likely-SRS patients (76.7%) displayed either 11p15 ICR1 hypomethylation (n=35; 58.3%) or maternal UPD of chromosome 7 (mUPD7) (n=11; 18.3%). Eight Unlikely-SRS patients had neither ICR1 hypomethylation nor mUPD7, whereas one patient had mUPD7. The clinical score and molecular results yielded four groups that differed significantly overall and for individual scoring system factors. Further molecular screening led identifying chromosomal abnormalities in Likely-SRS-double-negative and Unlikely-SRS groups. Four Likely-SRS-double negative patients carried a DLK1/GTL2 IG-DMR hypomethylation, a mUPD16; a mUPD20 and a de novo 1q21 microdeletion. Conclusions This new scoring system is very sensitive (98%) for the detection of patients with SRS with demonstrated molecular abnormalities. Given its clinical and molecular heterogeneity, SRS could be considered as a spectrum. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01293084; https://hal.sorbonne-universite.fr/hal-01293084Test; https://hal.sorbonne-universite.fr/hal-01293084/documentTest; https://hal.sorbonne-universite.fr/hal-01293084/file/J%20Med%20Genet-2015-Azzi-446-53.pdfTest |
| DOI: | 10.1136/jmedgenet-2014-102979 |
| الإتاحة: | https://doi.org/10.1136/jmedgenet-2014-102979Test https://hal.sorbonne-universite.fr/hal-01293084Test https://hal.sorbonne-universite.fr/hal-01293084/documentTest https://hal.sorbonne-universite.fr/hal-01293084/file/J%20Med%20Genet-2015-Azzi-446-53.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.A9A9F416 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/jmedgenet-2014-102979 |
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