دورية أكاديمية
Clinical significance and prognostic value of hemostasis parameters in 337 patients with acute infective endocarditis
| العنوان: | Clinical significance and prognostic value of hemostasis parameters in 337 patients with acute infective endocarditis |
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| المؤلفون: | Zampino R., Iossa D., Ursi M. P., Bertolino L., Karruli A., Molaro R., Esposito G., Vitrone M., D'amico F., Albisinni R., Durante-Mangoni E. |
| المساهمون: | Zampino, R., Iossa, D., Ursi, M. P., Bertolino, L., Karruli, A., Molaro, R., Esposito, G., Vitrone, M., D'Amico, F., Albisinni, R., Durante-Mangoni, E. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
| مصطلحات موضوعية: | APTT, Biomarker, D-dimer, Embolism, Prognosis |
| الوصف: | (1) Background: The aim of this study was to assess the clinical significance and prognostic role of the main hemostasis parameters in infective endocarditis (IE): prothrombin time as international normalized ratio (PT-INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimers, platelet count, homocysteine. (2) Methods: We studied 337 patients with IE. Clinical, hemato-chemical and echocardiography parameters were analyzed. Coagulation parameters were measured on admission. (3) Results: D-dimers levels (p = 0.012) and a prolonged PT-INR (p = 0.013) were associated with higher in-hospital mortality, while prolonged aPTT (p = 0.021) was associated with increased 1-year mortality. Staphylococcus aureus (S. aureus) infection (p = 0.003), prosthetic valve endocarditis (PVE) (p = 0.001), surgical indication (p = 0.002) and higher D-dimer levels (p = 0.005) were independent predictors of in-hospital mortality. PVE (p = 0.001), a higher Charlson Comorbidity Index (p = 0.049), surgical indication (p = 0.001) and prolonged aPTT (p = 0.012) were independent pre-dictors of 1-year mortality. Higher levels of D-dimers (p < 0.001) and a shorter aPTT (p < 0.001) were associated with embolic complications of IE. S. aureus etiology was bound to higher D-dimers levels (p <0.001) and a shorter aPTT (p = 0.006). (4) Conclusions: Elevated D-dimers are associated with a higher risk for in-hospital mortality in IE patients. High D-dimers and a short aPTT are associated with a higher risk for embolic events in IE. A longer aPTT is associated with 1-year mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34830670; info:eu-repo/semantics/altIdentifier/wos/WOS:000727288500001; volume:10; issue:22; firstpage:5386; journal:JOURNAL OF CLINICAL MEDICINE; http://hdl.handle.net/11591/463648Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85119878058 |
| DOI: | 10.3390/jcm10225386 |
| الإتاحة: | https://doi.org/10.3390/jcm10225386Test http://hdl.handle.net/11591/463648Test |
| رقم الانضمام: | edsbas.A966CC28 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jcm10225386 |
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