دورية أكاديمية
IL-10-producing regulatory cells impact on celiac disease evolution
| العنوان: | IL-10-producing regulatory cells impact on celiac disease evolution |
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| المؤلفون: | Passerini, Laura, Amodio, Giada, Bassi, Virginia, Vitale, Serena, Mottola, Ilaria, Di Stefano, Marina, Fanti, Lorella, Sgaramella, Paola, Ziparo, Chiara, Furio, Silvia, Auricchio, Renata, Barera, Graziano, Di Nardo, Giovanni, Troncone, Riccardo, Gianfrani, Carmen, Gregori, Silvia |
| المساهمون: | Passerini, Laura, Amodio, Giada, Bassi, Virginia, Vitale, Serena, Mottola, Ilaria, Di Stefano, Marina, Fanti, Lorella, Sgaramella, Paola, Ziparo, Chiara, Furio, Silvia, Auricchio, Renata, Barera, Graziano, Di Nardo, Giovanni, Troncone, Riccardo, Gianfrani, Carmen, Gregori, Silvia |
| سنة النشر: | 2024 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Gliadin-specific T cell, Interleukin 10, Potential celiac disease, T regulatory type 1, Tolerogenic dendritic cell, Villous atrophy |
| الوصف: | Celiac Disease (CD) is a T-cell mediated disorder caused by immune response to gluten, although the mechanisms underlying CD progression are still elusive. We analyzed immune cell composition, plasma cytokines, and gliadin-specific T-cell responses in patients with positive serology and normal intestinal mucosa (potential-CD) or villous atrophy (acute-CD), and after gluten-free diet (GFD). We found: an inflammatory signature and the presence of circulating gliadin-specific IFN-γ+ T cells in CD patients regardless of mucosal damage; an increased frequency of IL-10-secreting dendritic cells (DC-10) in the gut and of circulating gliadin-specific IL-10-secreting T cells in potential-CD; IL-10 inhibition increased IFN-γ secretion by gliadin-specific intestinal T cells from acute- and potential-CD. On GFD, inflammatory cytokines normalized, while IL-10-producing T cells accumulated in the gut. We show that IL-10-producing cells are fundamental in controlling pathological T-cell responses to gluten: DC-10 protect the intestinal mucosa from damage and represent a marker of potential-CD. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | volume:260; journal:CLINICAL IMMUNOLOGY; https://hdl.handle.net/11588/955009Test |
| DOI: | 10.1016/j.clim.2024.109923 |
| الإتاحة: | https://doi.org/10.1016/j.clim.2024.109923Test https://hdl.handle.net/11588/955009Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A965F8BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.clim.2024.109923 |
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