دورية أكاديمية
Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum)
| العنوان: | Alteration of Neutrophil Reactive Oxygen Species Production by Extracts of Devil’s Claw (Harpagophytum) |
|---|---|
| المؤلفون: | Mbaki Muzila, Kimmo Rumpunen, Helen Wright, Helen Roberts, Melissa Grant, Hilde Nybom, Jasna Sehic, Anders Ekholm, Cecilia Widén |
| المصدر: | Oxidative Medicine and Cellular Longevity, Vol 2016 (2016) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2016 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Cytology, QH573-671 |
| الوصف: | Harpagophytum, Devil’s Claw, is a genus of tuberiferous xerophytic plants native to southern Africa. Some of the taxa are appreciated for their medicinal effects and have been traditionally used to relieve symptoms of inflammation. The objectives of this pilot study were to investigate the antioxidant capacity and the content of total phenols, verbascoside, isoverbascoside, and selected iridoids, as well as to investigate the capacity of various Harpagophytum taxa in suppressing respiratory burst in terms of reactive oxygen species produced by human neutrophils challenged with phorbol myristate acetate (PMA), opsonised Staphylococcus aureus, and Fusobacterium nucleatum. Harpagophytum plants were classified into different taxa according to morphology, and DNA analysis was used to confirm the classification. A putative new variety of H. procumbens showed the highest degree of antioxidative capacity. Using PMA, three Harpagophytum taxa showed anti-inflammatory effects with regard to the PBS control. A putative hybrid between H. procumbens and H. zeyheri in contrast showed proinflammatory effect on the response of neutrophils to F. nucleatum in comparison with treatment with vehicle control. Harpagophytum taxa were biochemically very variable and the response in suppressing respiratory burst differed. Further studies with larger number of subjects are needed to corroborate anti-inflammatory effects of different taxa of Harpagophytum. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1942-0900 1942-0994 |
| العلاقة: | http://dx.doi.org/10.1155/2016/3841803Test; https://doaj.org/toc/1942-0900Test; https://doaj.org/toc/1942-0994Test; https://doaj.org/article/c270f948d04641c4a1bb51ea59b83ac0Test |
| DOI: | 10.1155/2016/3841803 |
| الإتاحة: | https://doi.org/10.1155/2016/3841803Test https://doaj.org/article/c270f948d04641c4a1bb51ea59b83ac0Test |
| رقم الانضمام: | edsbas.A9238425 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19420900 19420994 |
|---|---|
| DOI: | 10.1155/2016/3841803 |