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Cancer classification using the Immunoscore: a worldwide task force

التفاصيل البيبلوغرافية
العنوان: Cancer classification using the Immunoscore: a worldwide task force
المؤلفون: Galon Jérôme, Pagès Franck, Marincola Francesco M, Angell Helen K, Thurin Magdalena, Lugli Alessandro, Zlobec Inti, Berger Anne, Bifulco Carlo, Botti Gerardo, Tatangelo Fabiana, Britten Cedrik M, Kreiter Sebastian, Chouchane Lotfi, Delrio Paolo, Arndt Hartmann, Asslaber Martin, Maio Michele, Masucci Giuseppe V, Mihm Martin, Vidal-Vanaclocha Fernando, Allison James P, Gnjatic Sacha, Hakansson Leif, Huber Christoph, Singh-Jasuja Harpreet, Ottensmeier Christian, Zwierzina Heinz, Laghi Luigi, Grizzi Fabio, Ohashi Pamela S, Shaw Patricia A, Clarke Blaise A, Wouters Bradly G, Kawakami Yutaka, Hazama Shoichi, Okuno Kiyotaka, Wang Ena, O'Donnell-Tormey Jill, Lagorce Christine, Pawelec Graham, Nishimura Michael I, Hawkins Robert, Lapointe Réjean, Lundqvist Andreas, Khleif Samir N, Ogino Shuji, Gibbs Peter, Waring Paul, Sato Noriyuki, Torigoe Toshihiko, Itoh Kyogo, Patel Prabhu S, Shukla Shilin N, Palmqvist Richard, Nagtegaal Iris D, Wang Yili, D'Arrigo Corrado, Kopetz Scott, Sinicrope Frank A, Trinchieri Giorgio, Gajewski Thomas F, Ascierto Paolo A, Fox Bernard A
المصدر: Journal of Translational Medicine, Vol 10, Iss 1, p 205 (2012)
بيانات النشر: BMC
سنة النشر: 2012
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: Medicine
الوصف: Prediction of clinical outcome in cancer is usually achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC/UICC-TNM classification) summarizes data on tumor burden (T), presence of cancer cells in draining and regional lymph nodes (N) and evidence for metastases (M). However, it is now recognized that clinical outcome can significantly vary among patients within the same stage. The current classification provides limited prognostic information, and does not predict response to therapy. Recent literature has alluded to the importance of the host immune system in controlling tumor progression. Thus, evidence supports the notion to include immunological biomarkers, implemented as a tool for the prediction of prognosis and response to therapy. Accumulating data, collected from large cohorts of human cancers, has demonstrated the impact of immune-classification, which has a prognostic value that may add to the significance of the AJCC/UICC TNM-classification. It is therefore imperative to begin to incorporate the ‘Immunoscore’ into traditional classification, thus providing an essential prognostic and potentially predictive tool. Introduction of this parameter as a biomarker to classify cancers, as part of routine diagnostic and prognostic assessment of tumors, will facilitate clinical decision-making including rational stratification of patient treatment. Equally, the inherent complexity of quantitative immunohistochemistry, in conjunction with protocol variation across laboratories, analysis of different immune cell types, inconsistent region selection criteria, and variable ways to quantify immune infiltration, all underline the urgent requirement to reach assay harmonization. In an effort to promote the Immunoscore in routine clinical settings, an international task force was initiated. This review represents a follow-up of the announcement of this initiative, and of the J Transl Med. editorial from January 2012. ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1479-5876
العلاقة: http://www.translational-medicine.com/content/10/1/205Test; https://doaj.org/toc/1479-5876Test; https://doaj.org/article/1cc05322536f4e12a15612df8f575f17Test
DOI: 10.1186/1479-5876-10-205
الإتاحة: https://doi.org/10.1186/1479-5876-10-205Test
https://doaj.org/article/1cc05322536f4e12a15612df8f575f17Test
رقم الانضمام: edsbas.A8D09CC3
قاعدة البيانات: BASE
الوصف
تدمد:14795876
DOI:10.1186/1479-5876-10-205